2 STRAINS OF STREPTOCOCCUS-UBERIS, OF DIFFERING ABILITY TO CAUSE CLINICAL MASTITIS, DIFFER IN THEIR ABILITY TO RESIST SOME HOST DEFENSE FACTORS
2 STRAINS OF STREPTOCOCCUS-UBERIS, OF DIFFERING ABILITY TO CAUSE CLINICAL MASTITIS, DIFFER IN THEIR ABILITY TO RESIST SOME HOST DEFENSE FACTORS
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DOI：
10.1016/s0034-5288(18)31052-x
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发表时间：
1990-07-01
影响因子：
2.4
通讯作者：
WILLIAMS, MR
中科院分区：
文献类型：
--
作者：
LEIGH, JA;FIELD, TR;WILLIAMS, MR
两株Uberis链球菌(0140J和EF20)在感染乳腺和引起临床乳房炎的能力方面存在显著差异，它们对某些宿主防御机制的抵抗力也存在相关差异。两个菌株都能产生透明质酸胶囊，但感染能力更强的菌株0140J比EF20更能抵抗牛中性粒细胞的吞噬和杀伤。EF20菌株生长稳定期的包膜丢失并不影响其对吞噬的抵抗力。菌株0140J在原料脱脂奶中的生长速度也比EF20快，但二硫苏糖醇基本上逆转了这种抑制作用，表明乳过氧化物酶系统参与了原料奶的抑制作用。
Two strains of Streptococcus uberis (0140J and EF20), previously shown to differ markedly in their ability to infect the mammary gland and cause clinical mastitis, showed correlated differences in their resistance to some host defence mechanisms. Both strains produced a hyaluronic acid capsule but strain 0140J, the more infective, was more resistant than EF20 to phagocytosis and killing by bovine neutrophils. Loss of the capsule from strain EF20 during the stationary phase of growth did not affect its resistance to phagocytosis. Strain 0140J also grew more rapidly than EF20 in raw skimmed milk but dithiothreitol substantially reversed this inhibition, suggesting the involvement of the lactoperoxidase system in the inhibitory effect of raw milk.