On the resolution of fenfluramine.
On the resolution of fenfluramine.
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关于芬氟拉明的溶解度。
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
F. Carroll
中科院分区：
文献类型：
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作者：
A. Morehead;R. A. Reges;A. Lewin;F. Carroll
用（+）-二苯甲酰基酒石酸拆分芬氟拉明得到（+）-芬氟拉明，这与文献声称（-）-芬氟拉明是通过使用（+）-二苯甲酰基酒石酸得到的相矛盾。中间体二苯甲酰酒石酸盐已被充分表征，芬氟拉明对映体的绝对构型已被证实是如先前所建立的。使用（-）-二苯甲酰基酒石酸，然后使用（+）-二苯甲酰基酒石酸是获得芬氟拉明对映体的优选方法。
Resolution of fenfluramine with (+)-dibenzoyltartaric acid affords (+)-fenfluramine in contradiction of literature claims that (-)-fenfluramine is obtained by use of (+)-dibenzoyltartaric acid. The intermediate dibenzoyltartrate salt has been fully characterized and the absolute configuration of the enantiomers of fenfluramine has been confirmed to be as previously established. Use of (-)-dibenzoyltartaric acid, followed by use of (+)-dibenzoyltartaric acid is the preferred method for obtaining both fenfluramine enantiomers.