Dynamics of the actin cytoskeleton mediates receptor cross talk: An emerging concept in tuning receptor signaling.
Dynamics of the actin cytoskeleton mediates receptor cross talk: An emerging concept in tuning receptor signaling.
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DOI：
10.1083/jcb.201504137
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发表时间：
2016-02-01
期刊：
影响因子：
--
通讯作者：
Treanor B
中科院分区：
文献类型：
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作者：
Mattila PK;Batista FD;Treanor B
最近的证据暗示肌动蛋白细胞骨架在受体信号的控制。这可能在免疫受体（如B细胞受体）的背景下特别重要，其中信号失调可导致自身免疫和恶性肿瘤。在这里，我们讨论肌动蛋白细胞骨架在控制受体区隔化、动力学和聚类中的作用，作为一种通过控制与蛋白质伴侣的相互作用来调节受体信号的手段。我们认为肌动蛋白细胞骨架是通过调节蛋白质动力学和聚类来实现受体串扰的一个整合点。我们讨论了这种通过细胞骨架的串扰对配体诱导和免疫细胞生存所必需的低水平构成（强直）信号的影响。
Recent evidence implicates the actin cytoskeleton in the control of receptor signaling. This may be of particular importance in the context of immune receptors, such as the B cell receptor, where dysregulated signaling can result in autoimmunity and malignancy. Here, we discuss the role of the actin cytoskeleton in controlling receptor compartmentalization, dynamics, and clustering as a means to regulate receptor signaling through controlling the interactions with protein partners. We propose that the actin cytoskeleton is a point of integration for receptor cross talk through modulation of protein dynamics and clustering. We discuss the implication of this cross talk via the cytoskeleton for both ligand-induced and low-level constitutive (tonic) signaling necessary for immune cell survival.