Puberty in chronically diseased patients
Puberty in chronically diseased patients
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DOI：
10.1159/000058102
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发表时间：
2002-01-01
期刊：
影响因子：
--
通讯作者：
Simon, D
中科院分区：
文献类型：
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作者：
Simon, D
患有慢性疾病的患者经常报告青春期延迟开始和青春期生长突增减少。这些患者青春期异常的基础是多因素的。营养缺乏可能导致生长障碍和青春期延迟。在这些患者中可观察到食物供应不足和/或进食障碍和/或营养吸收不良。此外，患有慢性肺病、感染或炎症的患者通常需要增加能量供应。更具体的因素，由于疾病本身可能涉及生长和青春期障碍。生长激素（GH）-胰岛素样生长因子（IGF）1轴和促性腺激素分泌的异常在慢性肾功能衰竭、囊性纤维化和克罗恩病患者中已有报道。最近，它已被证明，在慢性疾病，如青少年特发性关节炎产生的细胞因子可能会影响GH-IGF 1轴。最后，这些患者经常使用的伴随药物，即皮质类固醇，可能导致青春期延迟和青春期发育不良。版权所有（C）2002 S. Karger AG，巴塞尔。
Delayed onset of puberty and a reduced pubertal growth spurt are often reported in patients suffering from chronic diseases. The basis of abnormal puberty in these patients is multifactorial. Nutritional deficiency may contribute to growth disorders and delayed puberty. Insufficient food supply and/or eating disorders and/or malabsorption of nutrients can be observed in these patients. Moreover, increased energy supplies are often needed in patients with chronic lung disease, infection or inflammation. More specific factors due to the disease itself may be involved in growth and puberty disorders. Abnormalities of the growth hormone (GH)-insulin-like growth factor (IGF)1 axis and gonadotrophin secretion have been described in patients with chronic renal failure, cystic fibrosis and Crohn's disease. More recently, it has been shown that cytokines produced during chronic diseases such as juvenile idiopathic arthritis may affect the GH-IGF1 axis. Finally, concomitant medication, namely corticosteroids, which are often given to these patients, may contribute to delayed puberty and poor pubertal growth. Copyright (C) 2002 S. Karger AG, Basel.