CARMA1-mediated NF-kappaB and JNK activation in lymphocytes.
CARMA1-mediated NF-kappaB and JNK activation in lymphocytes.
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DOI：
10.1111/j.1600-065x.2008.00749.x
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发表时间：
2009-03
影响因子：
8.7
通讯作者：
Lin X
中科院分区：
文献类型：
--
作者：
Blonska M;Lin X
转录因子核因子-κB（NF-κB）和Jun N末端激酶（JNK）的激活在淋巴细胞活化和增殖的调节中起关键作用。这些信号通路的失调导致不适当的免疫反应，并有助于白血病/淋巴瘤的发展。支架蛋白CARMA 1 [半胱天冬酶募集结构域（CARD）膜相关鸟苷酸激酶（MAGUK）蛋白1]在B和T淋巴细胞中的NF-κB和JNK 2/c-Jun复合物的调节中具有核心作用。在过去的几年中，大量的工作已经完成，以揭示CARMA 1及其信号传导伙伴Bcl 10（B cell CLL-lymphoma 10）和MALT 1（mucosa-associated lymphoid tissue 1）被激活并介导NF-κB和JNK活化的机制。本文综述了CARMA 1在NF-κB和JNK信号通路中的作用，并对CARMA 1在NF-κB和JNK信号通路中的研究进展进行了综述。
Activation of transcription factor nuclear factor-κB (NF-κB) and Jun N-terminal kinase (JNK) play the pivotal roles in regulation of lymphocyte activation and proliferation. Deregulation of these signaling pathways leads to inappropriate immune response and contributes to the development of leukemia/lymphoma. The scaffold protein CARMA1 [caspase-recruitment domain (CARD) membrane-associated guanylate kinase (MAGUK) protein 1] has a central role in regulation of NF-κB and the JNK2/c-Jun complex in both B and T lymphocytes. During last several years, the tremendous work has been done to reveal the mechanism by which CARMA1 and its signaling partners, Bcl10 (B cell CLL-lymphoma 10) and MALT1 (mucosa-associated lymphoid tissue 1), are activated and mediate NF-κB and JNK activation. In this review, we summarize our findings in revealing the roles of CARMA1 in the NF-κB and JNK signaling pathways in the context of recent advances in this field.