Effects of hypothalmic implants of GH on anterior pituitary weight and GH concentration.
Effects of hypothalmic implants of GH on anterior pituitary weight and GH concentration.
复制标题
GH 下丘脑植入对垂体前叶重量和 GH 浓度的影响。
DOI：
10.1210/endo-85-4-725
复制
发表时间：
1969
期刊：
影响因子：
4.8
通讯作者：
S. Mccann
中科院分区：
文献类型：
--
作者：
S. H. Katz;M. Molitch;S. Mccann
与正常对照组或胆固醇植入对照组相比，下丘脑植入 GH 与胆固醇混合后，在植入后 7 天内，垂体前叶的绝对重量和相对重量均有所减少。类似的 LH 或催乳素植入物未能改变垂体重量。根据生物测定的估计，垂体重量的减少持续了另外 7 天，并且与 14 天时垂体 GH 浓度的减少有关。与植入胆固醇的对照组相比，植入后 4-7 小时体重增加明显小幅下降，这表明植入 GH 的大鼠的内源性和外源性 GH 释放可能有所减少。植入的 GH 剂量与垂体重量减少之间存在明显的剂量反应关系。在下丘脑的多个位点植入 GH 都是有效的，而在大脑皮层植入激素则产生最小的影响。结论是 GH 主要作用于...
Hypothalamic implants of GH mixed with cholesterol produced a reduction in both absolute and relative weight of the anterior pituitary within 7 days of implantation on comparison with either normal or cholesterol-implanted controls. Similar implants of LH or prolactin failed to modify pituitary weight. The reduction in pituitary weight persisted for an additional 7 days and was associated with a reduction in pituitary GH concentration at 14 days as estimated by bioassay. Small decreases in body weight gain were apparent on comparison with cholesterol-implanted controls at 4–7 after implantation which indicate that endogenous plus exogenous GH release may have been reduced in the rats with GH implants. A dose-response relationship was evident between the dose of GH implanted and the reduction in pituitary weight. Implants of GH in a variety of hypothalamic loci were effective and a minimal effect was exerted by implants of the hormone in the cerebral cortex. It is concluded that GH acts centrally on the hy...