FeCl <sub>3</sub> ‐Catalyzed Diastereodivergent Sulfamidation of Diarylmethanol Diastereomixtures Bearing a Chiral Auxiliary Dependent on Catalyst Loading
FeCl <sub>3</sub> ‐Catalyzed Diastereodivergent Sulfamidation of Diarylmethanol Diastereomixtures Bearing a Chiral Auxiliary Dependent on Catalyst Loading
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FeCl <sub>3</sub> -催化二芳基甲醇非对映混合物的非对映异构磺酰胺化，该混合物带有取决于催化剂负载的手性助剂
DOI：
10.1002/ajoc.202100605
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发表时间：
2021
影响因子：
2.7
通讯作者：
Nakata Kenya
中科院分区：
文献类型：
--
作者：
Oda Ryoga;Yamamoto Hiroshi;Nakata Kenya
FeCl 3催化的，非对映异构体磺酰胺化的非对映异构体混合物的二芳基甲醇轴承的手性助剂实现，并被发现是依赖于催化剂负载。在这些条件下，各种底物携带不同的取代基上的芳环可以应用于这两种反应途径。磺酰胺部分很容易除去，得到相应的手性胺。利用本方法，可以有效地合成具有不同立体化学的手性磺酰胺类化合物。
The FeCl3‐catalyzed, diastereodivergent sulfamidation of diastereomixtures of diarylmethanols bearing a chiral auxiliary was achieved and was found to be dependent on the catalyst loading. Under these conditions, a variety of substrates bearing different substituents on their aromatic rings could be applied to both reaction pathways. The sulfamide moieties were easily removed to give the corresponding chiral amines. Chiral sulfamides with different stereochemistry were efficiently synthesized as organocatalysts using the present method.