Time trends in the prescription of statins for the primary prevention of cardiovascular disease in the United Kingdom: a cohort study using The Health Improvement Network primary care data.
Time trends in the prescription of statins for the primary prevention of cardiovascular disease in the United Kingdom: a cohort study using The Health Improvement Network primary care data.
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DOI：
10.2147/clep.s104258
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发表时间：
2016
影响因子：
3.9
通讯作者：
Petersen I
中科院分区：
文献类型：
--
作者：
O'Keeffe AG;Nazareth I;Petersen I
他汀类药物被广泛用于心血管疾病的一级预防。他汀类药物处方指南已经存在，但最近很少有关于处方趋势的分析，以及这些趋势如何随人口统计学变量而变化。使用健康改善网络初级保健数据库，使用1995年至2013年英国7，027，711人的数据计算他汀类药物治疗开始和他汀类药物处方患病率，总体和按性别、年龄组和社会经济贫困水平（汤森评分）分层。他汀类药物治疗开始率从1995年（0.51/1000人-年）到2006年（19.83/1000人-年）急剧上升，此后下降（2013年为10.76/1000人-年）。男性的启动率高于女性，60-85岁的个人启动率高于年轻或更年长的年龄组。在考虑了年龄和性别后，随着社会剥夺程度的增加，入学率略高。处方流行率从1995年（2.36/1000人-年）到2013年（128.03/1000人-年）急剧增加，随着时间的推移，男性的流行率通常高于女性。随着时间的推移，老年群体的患病率普遍较高，但在社会剥夺程度方面相似。随着时间的推移，他汀类药物在英国初级保健中的使用大大增加，一般老年患者更常使用他汀类药物，近年来，男性使用他汀类药物的比例似乎高于女性。在考虑了年龄和性别后，他汀类药物治疗的开始率随着社会剥夺程度的增加而增加。
Statins are widely prescribed for the primary prevention of cardiovascular disease. Guidelines exist for statin prescriptions, but there is little recent analysis concerning prescription trends over time and how these vary with respect to demographic variables. Using The Health Improvement Network primary care database, statin therapy initiation and statin prescription prevalence rates were calculated using data from 7,027,711 individuals across the UK for the years 1995 to 2013, overall and stratified by sex, age group, and socioeconomic deprivation level (Townsend score). Statin therapy initiation rates rose sharply from 1995 (0.51 per 1,000 person-years) up to 2006 (19.83 per 1,000 person-years) and thereafter declined (10.76 per 1,000 person-years in 2013). Males had higher initiation rates than females and individuals aged 60–85 years had higher initiation rates than younger or more elderly age groups. Initiation rates were slightly higher as social deprivation level increased, after accounting for age and sex. Prescription prevalence increased sharply from 1995 (2.36 per 1,000 person-years) to 2013 (128.03 per 1,000 person-years) with males generally having a higher prevalence rate, over time, than females. Prevalence rates over time were generally higher for older age groups but were similar with respect to social deprivation level. The uptake of statins within UK primary care has increased greatly over time with statins being more commonly prescribed to older patients in general and, in recent years, males appear to have been prescribed statins at higher rates than females. After accounting for age and sex, the statin therapy initiation rate increases with the level of social deprivation.