VOLTAGE OSCILLATIONS IN THE BARNACLE GIANT MUSCLE-FIBER
VOLTAGE OSCILLATIONS IN THE BARNACLE GIANT MUSCLE-FIBER
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DOI：
10.1016/s0006-3495(81)84782-0
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发表时间：
1981-01-01
影响因子：
3.4
通讯作者：
LECAR, H
中科院分区：
文献类型：
--
作者：
MORRIS, C;LECAR, H
Barnacle muscle fibers subjected to constant current stimulation produce a variety of types of oscillatory behavior when the internal medium contains the Ca2+ chelator EGTA [ethylene glycol bis (.beta.-aminoethyl ether)N,N,N'',N''-tetraacetic acid]. Oscillations are abolished if Ca2+ is removed from the external medium, or if the K+ conductance is blocked. Available voltage-clamp data indicate that the cell''s active conductance systems are exceptionally simple. Given the complexity of barnacle fiber voltage behavior, this seems paradoxical. An analysis of the possible modes of behavior available to a system of 2 noninactivating conductance mechanisms is given which indicates a good correspondence to the types of behavior exhibited by barnacle fiber. The differential equations of a simple equivalent circuit for the fiber are dealt with by some of the mathematical techniques of nonlinear mechanics. General features of the system are: a propensity to produce damped or sustained oscillations over a rather broad parameter range, and considerable latitude in the shape of the oscillatory potentials. For cells subject to changeable parameters (either from cell to cell or with time during cellular activity), a system dominated by 2 noninactivating conductances can exhibit varied oscillatory and bistable behavior.
