Mapping polygenes.
Mapping polygenes.
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DOI：
10.1146/annurev.genet.27.1.205
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发表时间：
1993
影响因子：
11.1
通讯作者：
S. Tanksley
中科院分区：
文献类型：
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作者：
S. Tanksley
大突变（具有主要表型效应的等位基因）极大地简化了遗传学家的工作。无翅苍蝇、无毛老鼠和矮植物都可以由单个位点的大突变来调节。存在大突变的位点很容易用孟德尔遗传学的工具来研究，因为它们允许从个体的表型中明确地推断出特定位点的基因型。正是由于这个原因，直到最近，遗传连锁图上显示的大多数位点都与存在大突变的位点相对应。而宏观
Macromutations (alleles with major phenotypic effects) have greatly simpli fied the lives of geneticists. Wingless flies, hairless mice, and dwarf plants can all be conditioned by macromutations at single loci. Loci for which macromutations exist are easy to study with the tools of Mendelian genetics since they allow the genotype of a particular locus to be unambiguously inferred from the phenotype of the individuaL It is for this reason that, until recently, most of the loci displayed on genetic linkage maps corre sponded to loci for which macromutations were available. While macro-