TOWARD AN OUTLINE OF THE TOPOGRAPHY OF A REALISTIC PROTEIN-FOLDING FUNNEL
TOWARD AN OUTLINE OF THE TOPOGRAPHY OF A REALISTIC PROTEIN-FOLDING FUNNEL
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DOI：
10.1073/pnas.92.8.3626
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发表时间：
1995-04-11
影响因子：
11.1
通讯作者：
SOCCI, ND
中科院分区：
文献类型：
--
作者：
ONUCHIC, JN;WOLYNES, PG;SOCCI, ND
关于熔球结构和动力学的实验信息可以对折叠高度螺旋蛋白质的能量景观特征进行估计，并辅以塌缩杂聚物中的螺旋-螺旋转变理论。将小晶格模型的模拟与具有更多自由度结果的真实蛋白质相关联的相应状态定律。这种对应关系揭示了“极简主义”晶格结果与最近关于折叠过渡态和熔球的固有特征程度的实验结果之间的相似之处，并且还指出了进一步实验的需要。
Experimental information on the structure and dynamics of molten globules gives estimates for the energy landscape's characteristics for folding highly helical proteins, when supplemented by a theory of the helix-coil transition in collapsed heteropolymers. A law of corresponding states relating simulations on small lattice models to real proteins possessing many more degrees of freedom results. This correspondence reveals parallels between ''minimalist'' lattice results and recent experimental results for the degree of native character of the folding transition state and molten globule and also pinpoints the needs of further experiments.