PROTEIN-INDUCED HYPERCALCIURIA - LONGER TERM STUDY
PROTEIN-INDUCED HYPERCALCIURIA - LONGER TERM STUDY
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DOI：
10.1093/ajcn/32.4.741
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发表时间：
1979-01-01
影响因子：
7.1
通讯作者：
MARGEN, S
中科院分区：
文献类型：
--
作者：
ALLEN, LH;ODDOYE, EA;MARGEN, S
Urine Ca excretion is known to be directly correlated with the level of dietary protein intake. The persistence of hypercalciuria induced by the consumption of high protein diets, and the mechanism of the calciuric response were examined. In a 95 day metabolic study, each of 6 adult male subjects received formula diets supplying 12 g N or 36 g N, and approximately 1400 mg Ca/day. Urine Ca increased rapidly and significantly from an average of 191 mg/day on the 12 g N diet to 277 mg/day on the 36 g N diet. There was no significant difference in the apparent absorption of Ca, so that overall Ca balance was -37 mg/day on the 12 g N diet, and significantly lower at -137 mg/day in subjects consuming the high protein diet. Levels of urinary hydroxyproline, serum insulin, and parathyroid hormone were not significantly increased by high intakes of protein. A decrease in the fractional reabsorption of Ca by the kidney seems to be the most likely cause of the protein-induced hypercalciuria. The consumption of high Ca diets is unlikely to prevent the negative Ca balance and probable bone loss induced by the consumption of high protein diets.
