Identification of local selective sweeps in human populations since the exodus from Africa.
Identification of local selective sweeps in human populations since the exodus from Africa.
复制标题
确定自非洲迁徙以来当地人口的选择性清除。
作者：
Å. Johansson;U. Gyllensten
在通向现代人类的谱系中，已经使用比较基因组学和SNP体系结构来研究人类基因组的选择。随着非洲人口的外逃和对其他大陆的殖民，人类人口已经适应了一系列不同的环境条件。使用一种联合分析群体内和群体间单倍型区块长度和等位基因频率变异(F(ST))的新方法，我们已经确定了可能受到局部选择影响的染色体区域。基于在71名非裔美国人、欧洲裔美国人和汉族人后裔中输入的160万个SNP，我们已经确定了一些基因和非编码区，这些基因和非编码区是在过去10万年中经历过局部正选择的候选基因。这些基因包括与皮肤色素沉着(SLC24A5)和饮食适应(LCT)有关的基因。这些局部选择性扫描涉及的基因清单与使用其他方法对人类种群进行的其他研究中涉及的基因部分重叠，但与自人类和黑猩猩祖先分化以来在5-7 MYR中被选择的基因几乎没有重叠。我们的分析为详细研究进化事件提供了基因组中的焦点，这些事件在人类探索世界不同地区时塑造了他们的种群。
Selection on the human genome has been studied using comparative genomics and SNP architecture in the lineage leading to modern humans. In connection with the African exodus and colonization of other continents, human populations have adapted to a range of different environmental conditions. Using a new method that jointly analyses haplotype block length and allele frequency variation (F(ST)) within and between populations, we have identified chromosomal regions that are candidates for having been affected by local selection. Based on 1.6 million SNPs typed in 71 individuals of African American, European American and Han Chinese descent, we have identified a number of genes and non-coding regions that are candidates for having been subjected to local positive selection during the last 100 000 years. Among these genes are those involved in skin pigmentation (SLC24A5) and diet adaptation (LCT). The list of genes implicated in these local selective sweeps overlap partly with those implicated in other studies of human populations using other methods, but show little overlap with those postulated to have been under selection in the 5-7 myr since the divergence of the ancestors of human and chimpanzee. Our analysis provides focal points in the genome for detailed studies of evolutionary events that have shaped human populations as they explored different regions of the world.
登录
查看更多内容
影响因子：
7
作者：
Akey, JM;Zhang, G;Shriver, MD
通讯作者：
Shriver, MD
影响因子：
9.8
作者：
Hamblin, MT;Di Rienzo, A
通讯作者：
Di Rienzo, A
影响因子：
7
作者：
Weir, BS;Cardon, LR;Hill, WG
通讯作者：
Hill, WG
患有 II 型（酪氨酸酶阳性）眼皮肤白化病 (OCA2) 的非洲裔美国人中 P 基因的多种突变。
影响因子：
3.5
作者：
Lee,ST;Nicholls,RD;Schnur,RE;Guida,LC;Lu-Kuo,J;Spinner,NB;Zackai,EH;Spritz,RA
通讯作者：
Spritz,RA
影响因子：
7
作者：
Carlson, CS;Thomas, DJ;Nickerson, DA
通讯作者：
Nickerson, DA