Leptin in teleostean fish, towards the origins of leptin physiology
Leptin in teleostean fish, towards the origins of leptin physiology
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DOI：
10.1016/j.jchemneu.2014.06.005
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发表时间：
2014-11-01
影响因子：
2.8
通讯作者：
Flik, Gert
中科院分区：
文献类型：
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作者：
Gorissen, Marnix;Flik, Gert
硬骨鱼瘦素于2005年首次克隆，比哺乳动物瘦素发现晚了十多年。这种延迟的原因在于哺乳动物和鱼类leptins之间非常差的一级序列保守性（类似于13-25%）。这些低的序列保守性表明了高度的分子进化性，并保证在硬骨鱼类中寻找不同的和原始的瘦素功能。事实上，由于硬骨鱼作为最早的脊椎动物的独特的系统发育位置和由于其外温性，这意味着硬骨鱼在改变其代谢方面比哺乳动物更灵活，瘦素可以在这种灵活性中发挥作用，因此获得了新的和原始的见解。过去十年的研究表明，瘦素在鱼类和哺乳动物中都是真正的多效性激素，除了调节食物摄入和体重、发育外，还调节应激轴和适应过程，例如水中的低氧水平。在这篇综述中，我们提供了一个概述的硬骨鱼瘦素在过去十年中所做的工作，并证明了权力的比较方法导致新的见解瘦素生理学的起源。(C)2014爱思唯尔有限公司版权所有。
Teleostean leptin was first cloned in 2005, more than a decade after the discovery of mammalian leptin. The reason for this delay lies in the very poor primary sequence conservation (similar to 13-25%) between mammalian and fish leptins. These low sequence conservations indicate a high degree of molecular evolvability and warrant a search for different and original functions of leptin in teleosts. Indeed, new and original insights are obtained because of the unique phylogenetic position of teleostean fish as the earliest vertebrates and because of their ectothermy, which means that teleosts are more flexible in changing their metabolism than mammals and leptin could play a role in this flexibility. Research during the last decade reveals that leptin is a truly pleiotropic hormone in fish and mammals alike, with functions among others in the regulation of food intake and body weight, development, but also in the regulation of the stress axis and acclimation processes to for instance low oxygen levels in the water. In this review, we provide an overview of the teleostean leptin work done in the last ten years, and demonstrate that the power of a comparative approach leads to new insights on the origins of leptin physiology. (C) 2014 Elsevier B.V. All rights reserved.