Magnetoreception of Photoactivated Cryptochrome 1 in Electrochemistry and Electron Transfer
Magnetoreception of Photoactivated Cryptochrome 1 in Electrochemistry and Electron Transfer
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DOI：
10.1021/acsomega.8b00645
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发表时间：
2018-05
期刊：
影响因子：
4.1
通讯作者：
Z. Zeng;Jianjun Wei;Yiyang Liu;Wendi Zhang;T. Mabe
中科院分区：
文献类型：
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作者：
Z. Zeng;Jianjun Wei;Yiyang Liu;Wendi Zhang;T. Mabe
隐花色素是一种黄素蛋白，其光化学作用对于与向光性和生物钟相关的关键功能非常重要。在本报告中，我们首次观察到固定在金电极上的隐花色素1（Cryptochrome 1）在蓝光照射下的磁响应。这些结果提出了磁场增强的光诱导电子转移到电极的伏安法，表现出磁响应速率常数和电流的变化。电子转移的机制，其中涉及光诱导自由基的CRY，是敏感的弱磁场;和长寿命的自由基FAD·-是负责检测到的电化学法拉第电流。作为光感受器，50 μT磁场对应的电子转移速率常数变化5.7%的发现可能对电磁场下磁场信号传导和昼夜节律钟功能的调节有意义。
Cryptochromes are flavoproteins whose photochemistry is important for crucial functions associated with phototropism and circadian clocks. In this report, we, for the first time, observed a magnetic response of the cryptochrome 1 (CRY1) immobilized at a gold electrode with illumination of blue light. These results present the magnetic field-enhanced photoinduced electron transfer of CRY1 to the electrode by voltammetry, exhibiting magnetic responsive rate constant and electrical current changes. A mechanism of the electron transfer, which involves photoinduced radicals in the CRY, is sensitive to the weak magnetic field; and the long-lived free radical FAD•– is responsible for the detected electrochemical Faradaic current. As a photoreceptor, the finding of a 5.7% rate constant change in electron transfer corresponding to a 50 μT magnetic field may be meaningful in regulation of magnetic field signaling and circadian clock function under an electromagnetic field.