High-Sensitivity C-Reactive Protein and Leptin Levels Related to Body Mass Index Changes Throughout Childhood
High-Sensitivity C-Reactive Protein and Leptin Levels Related to Body Mass Index Changes Throughout Childhood
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DOI：
10.1016/j.jpeds.2016.08.020
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发表时间：
2016-11-01
影响因子：
5.1
通讯作者：
Soriano-Guillen, Leandro
中科院分区：
文献类型：
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作者：
Navarro, Pilar;de Dios, Olaya;Soriano-Guillen, Leandro
目的分析健康学龄儿童高敏c反应蛋白（hs-CRP）水平与心血管危险因素的关系，并评价儿童期身体质量指数（BMI）类别的变化是否影响hs-CRP水平。研究设计我们测量了683名青春期前儿童和748名青少年的血清hs-CRP水平、脂质谱、胰岛素水平和瘦素水平。共有272名儿童参与了这两个队列的研究，青春期前（基线，6-8岁）和青少年（随访，12-16岁）。结果与正常体重（NW）相比，肥胖和超重（OW）青少年和肥胖青春期前儿童hs-CRP水平显著升高。hs-CRP水平最高的是在基线和随访时为OW的儿童，而在随访时从基线OW过渡到NW的儿童hs-CRP水平最低。在青春期前的儿童和青少年中，高密度脂蛋白胆固醇和载脂蛋白A-I水平在hs-CRP的各个分位中都有所下降，在6- 8岁的男孩和女孩以及12- 16岁的男孩中，最高和最低分位的浓度有显著差异（P < 0.001）。在青春期前儿童和青少年中，hs-CRP水平也与瘦素水平显著相关，hs-CRP水平在各组中显著升高（P < 0.001）。结论：儿童期从OW到NW的转变与hs-CRP水平下降到低于整个儿童期维持NW的儿童的水平有关。在我们的人群中，瘦素水平与hs-CRP水平密切相关，与BMI无关。我们的研究结果表明，肥胖相关的慢性炎症状态可以通过改善体重状态来逆转。
Objectives To analyze the association between high-sensitivity C-reactive protein (hs-CRP) levels and cardiovascular risk factors in healthy school children, and to evaluate whether changes in body mass index (BMI) category throughout childhood affect hs-CRP levels.Study design We measured serum hs-CRP levels, lipid profile, insulin levels, and leptin levels in 683 prepubertal children and 748 adolescents. A total of 272 children participated in the study in both cohorts, prepubertal (baseline; age 6-8 years) and adolescents (follow-up; age 12-16 years).Results Compared with their normal weight (NW) counterparts, hs-CRP levels were significantly higher in obese and overweight (OW) adolescents and obese prepubertal children. The highest hs-CRP levels were seen in children who were OW at baseline and at follow-up, and the lowest levels in those who transitioned from OW at baseline to NW at follow-up. High-density lipoprotein cholesterol and apolipoprotein A-I levels decreased across the hs-CRP tertile in both prepubertal children and adolescents, with significant differences (P < .001) in concentrations between the highest and lowest tertiles in 6- to 8-year-old boys and girls and in 12- to 16-year-old boys. The hs-CRP levels were also significantly associated with leptin levels in both prepubertal children and adolescents, with a significant increase across hs-CRP tertiles (P < .001).Conclusions The shift from OW to NW throughout childhood is associated with a decrease in hs-CRP level to below that observed in children who maintain NW throughout childhood. Leptin levels were strongly associated with hs-CRP levels in our population independent of BMI. Our findings suggest that an obesity-related chronic inflammatory state may be reversible by improving weight status.