Greater endogenous estrogen exposure is associated with longer telomeres in postmenopausal women at risk for cognitive decline
Greater endogenous estrogen exposure is associated with longer telomeres in postmenopausal women at risk for cognitive decline
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DOI：
10.1016/j.brainres.2010.10.033
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发表时间：
2011-03-16
期刊：
影响因子：
2.9
通讯作者：
Rasgon, Natalie L.
中科院分区：
文献类型：
--
作者：
Lin, Jue;Kroenke, Candyce H.;Rasgon, Natalie L.
较长的生育年限，从而更多地暴露于内源性雌激素可能与较低的风险与年龄有关的疾病的妇女。本研究探讨了估计内源性雌激素暴露和端粒长度（TL）和端粒酶活性，细胞衰老的两个生物标志物之间的关系，在一个样本的绝经后妇女在认知能力下降的风险。采用定量PCR方法测定外周血单个核细胞（PBMC）中的端粒长度，并通过TRAP（端粒重复扩增方案）测定端粒酶活性。研究对象为53名绝经后妇女（35名自然绝经，18名手术绝经），接受激素治疗（HT）至少一年或更长时间。生殖寿命的长度，计算为绝经年龄和初潮年龄之间的差异，被用作内源性雌激素暴露持续时间的代表。HT的时间长度是衡量外源性雌激素暴露持续时间的指标。我们发现，内源性雌激素暴露时间越长，TL越大（标准化β =0.06，Wald chi（2）=3.7，p=0.04），端粒酶活性越低（标准化β =-0.09，Wald chi（2）=5.0，p=0.03）。生育年限的长短也与短TL和高端粒酶的组合呈负相关（OR = 0.78，95%CI：0.63，0.97，p = 0.02）。在这项研究中，HT使用的长度与TL或端粒酶活性无关。结果提示内源性雌激素可能与延缓细胞衰老有关。这是第一个研究内源性雌激素，端粒长度和端粒酶活性之间的联系。(C)2010 Elsevier BV保留所有权利。
Longer duration of reproductive years of life and thus greater exposure to endogenous estrogen may be associated with a lower risk of age-related diseases in women. The present study examined the relationship between estimated endogenous estrogen exposure and telomere length (TL) and telomerase activity, two biomarkers of cellular aging, in a sample of postmenopausal women at risk for cognitive decline. Telomere length was measured using a quantitative PCR method and telomerase activity by TRAP (Telomere-Repeats Amplification Protocol) assay in peripheral blood mononuclear cells (PBMCs). Study subjects were 53 postmenopausal women (35 with natural and 18 with surgical menopause) receiving hormone therapy (HT) for at least one year or longer. Length of reproductive years of life, computed as the difference between age at menopause and age at menarche, was used as a proxy of duration of exposure to endogenous estrogen. Length of time on HT was the measure used for duration of exogenous estrogen exposure. We found that longer endogenous estrogen exposure was associated with greater TL (standardized beta=0.06, Wald chi(2)=3.7, p=0.04) and with lower telomerase activity (standardized beta=-0.09, Wald chi(2)=5.0, p=0.03). Length of reproductive years was also inversely associated with the combination of short TL and high telomerase (OR = 0.78, 95% CI: 0.63, 0.97, p = 0.02). Length of HT use was not associated with TL or telomerase activity in this study. The results suggest that the endogenous estrogens may be associated with deceleration of cellular aging. This is the first study to examine associations between endogenous estrogens, telomere length and telomerase activity. (C) 2010 Elsevier B.V. All rights reserved.