Spatiotemporal electrochemistry on flexible microelectrode arrays: Progress towards smart contact lens integration
Spatiotemporal electrochemistry on flexible microelectrode arrays: Progress towards smart contact lens integration
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DOI：
10.1016/j.snb.2019.126671
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发表时间：
2019-06
期刊：
影响因子：
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通讯作者：
Matthew Donora;E. González-Fernández;A. Vásquez Quintero;H. De Smet;I. Underwood
中科院分区：
文献类型：
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作者：
Matthew Donora;E. González-Fernández;A. Vásquez Quintero;H. De Smet;I. Underwood
我们展示了一个实时的时空电化学图，显示了与柔性微电极阵列接触的分析物的时间和位置变化浓度。在聚酰亚胺衬底上制作了厚度为11 μm的聚合物基器件，包括图案金金属化，具有8个可单独寻址的工作电极（直径30 μm）和一个集成的对电极。我们在每个电极上进行了重复的高速计时安培测量序列，并对数据进行处理以生成时空浓度图，其中观察了两种不同浓度的混相流体的大量流动、扩散混合和均质化等流体效应。该装置采用与现有智能隐形眼镜平台兼容的工艺制造，以期在未来的工作中开发集成传感器。我们相信这项技术在电化学智能隐形眼镜领域具有巨大的潜力，既可以引入新的功能，也可以提高我们从泪膜测量中得出准确和临床相关结论的能力。
We demonstrate a real-speed spatiotemporal electrochemical map showing both time- and position-varying concentration of an analyte in contact with a flexible microelectrode array. A polymer-based device of 11 μm in thickness comprising patterned gold metallisation on a polyimide substrate was fabricated, with eight individually addressable working electrodes (diameter 30 μm) and an integrated counter electrode. We performed a repeated sequence of high-speed chronoamperometric measurements at each electrode and processed the data to generate a spatiotemporal concentration map, in which a number of fluid effects, including bulk flow, diffusive mixing and homogenisation of two miscible fluids of different concentration were observed. This device was fabricated using processes compatible with an existing smart contact lens platform, with a view to develop integrated sensors in future work. We believe this technique has significant potential in the field of electrochemical smart contact lenses, both in introducing new functionality and in improving our ability to draw accurate and clinically-relevant conclusions from measurements made in the tear film.