Association of marine-origin N-3 polyunsaturated fatty acids consumption and functional mobility in the community-dwelling oldest old
Association of marine-origin N-3 polyunsaturated fatty acids consumption and functional mobility in the community-dwelling oldest old
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DOI：
10.1007/s12603-012-0389-1
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
M. Takayama;Y. Arai;Satoshi Sasaki;Michio Hashimoto;K. Shimizu;Yukiko Abe;N. Hirose
中科院分区：
文献类型：
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作者：
M. Takayama;Y. Arai;Satoshi Sasaki;Michio Hashimoto;K. Shimizu;Yukiko Abe;N. Hirose
目的探讨海洋n-3多不饱和脂肪酸（MOPUFA）、二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）的习惯性膳食摄入是否与85岁及以上社区老年人的功能活动性相关，设计一项横断面研究。设置一项以社区为基础的调查，在大学研究中心或家庭进行，基于.紧身裤417在542名参加东京最年长者总体健康调查的基线检查的参与者中，一项以社区为基础的长期研究，对居住在日本中部的最年长的老人进行了调查。管理饮食史问卷（BDHQ），并通过计时起身和行走试验评估功能活动性。测定血浆炎症生物标志物（C-反应蛋白、白细胞介素-6和肿瘤坏死因子-a）。我们使用多变量逻辑回归分析评估了MOPUFA习惯性摄入与功能活动性之间的横截面关联。在分析之前，在190名参与者中证实了本研究中BDHQ的验证（96名男子，94名妇女）的基础上的EPA和DHA的浓度在红细胞膜磷脂作为参考。获得了红细胞膜磷脂中DHA和EPA/DHA的浓度（斯皮尔曼r = 0.29 - 0.58，p <0.01）。多变量逻辑回归分析显示，EPA + DHA习惯性摄入量较低与男性功能活动性差显著相关，但与女性无关（OR（95%CI））EPA + DHA摄入量每增加1 SD; 0.55（0.33 - 0.91）、0.88（0.59 - 1.32），男性和女性分别）. ConclusionsHabitably摄入MOPUFA与功能的流动性在社区居住的最老的老人。
ObjectiveTo examine whether habitual dietary intake of marine-origin n-3 polyunsaturated fatty acids (MOPUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with functional mobility in the community-dwelling oldest old, 85 years or older, who are at high risk for physical disability.DesignA cross-sectional study.SettingA community-based survey conducted at university research center or home-based.ParticipantsFour hundred seventeen (189 men, 228 women) out of 542 participants in the baseline examination of the Tokyo Oldest Old Survey on Total Health, a community-based ongoing longitudinal study among the oldest old living in the center of Japan.MeasurementsHabitual dietary intake of MOPUFA was assessed by the brief-type self-administered diet history questionnaire (BDHQ), and functional mobility was assessed by the Timed Up and Go test. Plasma inflammatory biomarkers (C-reactive protein, interleukin-6 and tumor necrosis factor-a) were measured. We evaluated the cross-sectional association between habitual intake of MOPUFA and functional mobility using multivariate logistic regression analysis — Prior to the analysis, validation of BDHQ in this study was confirmed among 190 participants (96 men, 94 women) based on the EPA and DHA concentrations in the erythrocyte membrane phospholipids as reference.ResultsModerate correlation between estimated dietary intake of EPA/DHA and concentration of EPA/DHA in the erythrocyte membrane phospholipids was obtained (Spearman’s r=0.29–0.58, p<0.01). Multivariate logistic regression analysis revealed that a lower habitual intake of EPA+DHA was significantly associated with poor functional mobility in men but not in women (OR (95%CI) per 1 SD increase of EPA+DHA intake; 0.55 (0.33–0.91), 0.88 (0.59–1.32), men and women respectively).ConclusionsHabitual intake of MOPUFA was associated with functional mobility in community-dwelling oldest old men.