In vivo trabecular microcracks in human vertebral bone
In vivo trabecular microcracks in human vertebral bone
复制标题
DOI：
10.1016/8756-3282(96)88871-5
复制
发表时间：
1996-08-01
期刊：
影响因子：
4.1
通讯作者：
Fyhrie, DP
中科院分区：
文献类型：
--
作者：
Wenzel, TE;Schaffler, MB;Fyhrie, DP
对来自白人男性 (N = 19)、黑人男性 (N = 16)、白人女性 (N = 12) 和黑人女性 (N = 17) 的人椎体松质骨进行组织学检查，以确定体内微观裂纹（微损伤）的存在、数量密度和形态。观察到线性和交叉影线两种微裂纹，在小梁的中心部分和近表面都观察到线性微裂纹，小梁内部的微裂纹通常是长度约为 50 μm 的单个微裂纹，在水泥线和间质骨基质中都有发现，小梁表面附近的线性微裂纹通常是长度约为 80 pm 的多个平行裂纹，具有交叉影线外观的微裂纹不太常见，它们主要在垂直方向的小梁中观察到，并且通常被弥漫染色区域包围，双向方差分析显示男性和女性之间的微裂纹密度（Cr，Dn；#/mm（2））没有差异[平均值（SD）分别为5.13（5.02）与5.41（6.26）]，但白人的微裂纹密度明显高于黑人[7.00 (5.71) vs, 3.63 (4.98)，分别，p < 0.05]，白人男性的微裂纹密度显着高于黑人男性[分别为 7.60 (5.56) vs，2.21 (1.78)，p < 0.05]，虽然不具有统计学意义，但白人女性也比黑人女性具有更高的微裂纹密度，与股骨中报道的情况相反，回归分析发现对于四个种族性别组中的任何一个，脊柱中的微裂纹密度和年龄之间都没有统计学上显着的关系，然而，除了黑人女性之外，所有组的微裂纹密度和骨面积分数之间都发现了显着的幂关系，讨论了轴骨和四肢骨重塑率之间的差异及其对微损伤积累的影响。
Human vertebral cancellous bone from white males (N = 19), black males (N = 16), white females (N = 12), and black females (N = 17) was examined histologically for the presence, numerical density, and morphology of in vivo microscopic cracking (microdamage). Two patterns of microcracks, linear and cross-hatched, were observed, Linear microcracks were observed in both the central portion and near surfaces of trabeculae, Those inside trabeculae were usually single microcracks approximately 50 mu m in length and were found in both cement lines and in interstitial bone matrix, Linear microcracks near the trabecular surface were usually multiple parallel cracks approximately 80 pm in length, Microcracks with a cross-hatched appearance were less prevalent, They were observed primarily in vertically oriented trabeculae and were often surrounded by an area of diffuse staining, Two-way ANOVA revealed no differences in microcrack density (Cr,Dn; #/mm(2)) between males and females [mean (SD) 5.13 (5.02) vs, 5.41 (6.26), respectively], but whites had significantly higher microcrack density than blacks [7.00 (5.71) vs, 3.63 (4.98), respectively, p < 0.05], White males had a significantly higher microcrack density than black males [7.60 (5.56) vs, 2.21 (1.78), respectively, p < 0.05], Although not statistically significant, white females also had higher microcrack density than black females, In contrast to what has been reported in the femur, regression analysis found no statistically significant relationship between microcrack density in the spine and age for any of the four race-gender groups, However, significant power relationships were found between microcrack density and bone area fraction for all groups except for black females, The difference between axial and appendicular bone remodeling rates, and their implications for microdamage accumulation, are discussed.