Vagal stimulation induces expiratory lengthening in the in vitro neonate rat.
Vagal stimulation induces expiratory lengthening in the in vitro neonate rat.
复制标题
迷走神经刺激诱导体外新生大鼠呼气延长。
DOI：
10.1152/jappl.1997.83.5.1607
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
Feldman,JL
中科院分区：
文献类型：
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作者：
Mellen,NM;Feldman,JL
Mellen、Nicholas M. 和 Jack L. Feldman。迷走神经刺激可诱导体外新生大鼠呼气延长。应用。 Physiol.83(5): 1607–1611, 1997.—呼吸是由体内肺机械感受器反馈在循环周期的基础上调节的。我们在体外复制了这种调节，并测试了四种刺激方案，以确定哪些刺激方案最接近地复制了哺乳动物对肺机械感受器激活的体内反应。我们通过呼气时施加的电刺激或肺部充气来激活肺迷走神经传入通路，从而在体内产生呼气延长。在每种模式中，都应用瞬时刺激和强直刺激。在吸气终止后的一系列延迟内施加刺激。维持强直刺激直至随后吸气开始。所有刺激方式均延长呼气时间（P<0.05）。这些结果表明介导呼气持续时间的肺传入调节的神经回路保留在体外。
Mellen, Nicholas M., and Jack L. Feldman.Vagal stimulation induces expiratory lengthening in the in vitro neonate rat.J. Appl. Physiol.83(5): 1607–1611, 1997.—Respiration is modulated by lung mechanoreceptor feedback in vivo on a cycle-to-cycle basis. We replicated this modulation in vitro and tested four stimulus protocols to identify which of these most closely replicated in vivo responses to lung mechanoreceptor activation in mammals. We activated pulmonary vagal afferent pathways by electrical stimulation or by lung inflation, applied during expiration, which produces expiratory lengthening in vivo. In each modality, transient and tonic stimuli were applied. Stimuli were applied over a range of delays following inspiratory termination. Tonic stimuli were maintained until subsequent inspiratory onset. All stimulus modalities prolonged expiration (P< 0.05). These results indicate that the neural circuitry mediating pulmonary afferent modulation of expiratory duration is retained in vitro.