Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia.
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia.
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DOI：
10.1038/ng.2624
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发表时间：
2013-06
期刊：
影响因子：
30.8
通讯作者：
Kwiatkowski, Dominic P.
中科院分区：
文献类型：
--
作者：
Miotto, Olivo;Almagro-Garcia, Jacob;Manske, Magnus;MacInnis, Bronwyn;Campino, Susana;Rockett, Kirk A.;Amaratunga, Chanaki;Lim, Pharath;Suon, Seila;Sreng, Sokunthea;Anderson, Jennifer M.;Duong, Socheat;Nguon, Chea;Chuor, Char Meng;Saunders, David;Se, Youry;Lon, Chantap;Fukuda, Mark M.;Amenga-Etego, Lucas;Hodgson, Abraham V. O.;Asoala, Victor;Imwong, Mallika;Takala-Harrison, Shannon;Nosten, Francois;Su, Xin-zhuan;Ringwald, Pascal;Ariey, Frederic;Dolecek, Christiane;Tran Tinh Hien;Boni, Maciej F.;Cao Quang Thai;Amambua-Ngwa, Alfred;Conway, David J.;Djimde, Abdoulaye A.;Doumbo, Ogobara K.;Zongo, Issaka;Ouedraogo, Jean-Bosco;Alcock, Daniel;Drury, Eleanor;Auburn, Sarah;Koch, Oliver;Sanders, Mandy;Hubbart, Christina;Maslen, Gareth;Ruano-Rubio, Valentin;Jyothi, Dushyanth;Miles, Alistair;O'Brien, John;Gamble, Chris;Oyola, Samuel O.;Rayner, Julian C.;Newbold, Chris I.;Berriman, Matthew;Spencer, Chris C. A.;McVean, Gilean;Day, Nicholas P.;White, Nicholas J.;Bethell, Delia;Dondorp, Arjen M.;Plowe, Christopher V.;Fairhurst, Rick M.;Kwiatkowski, Dominic P.
We describe an analysis of genome variation in 825 Plasmodium falciparum samples from Asia and Africa that reveals an unusual pattern of parasite population structure at the epicentre of artemisinin resistance in western Cambodia. Within this relatively small geographical area we have discovered several distinct but apparently sympatric parasite subpopulations with extremely high levels of genetic differentiation. Of particular interest are three subpopulations, all associated with clinical resistance to artemisinin, which have skewed allele frequency spectra and remarkably high levels of haplotype homozygosity, indicative of founder effects and recent population expansion. We provide a catalogue of SNPs that show high levels of differentiation in the artemisinin-resistant subpopulations, including codon variants in various transporter proteins and DNA mismatch repair proteins. These data provide a population genetic framework for investigating the biological origins of artemisinin resistance and for defining molecular markers to assist its elimination.
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影响因子：
64.8
作者：
FOOTE, SJ;KYLE, DE;COWMAN, AF
通讯作者：
COWMAN, AF
DOI：
10.1056/nejmp1108322
发表时间：
2011-09-22
期刊：
The New England journal of medicine
影响因子：
--
作者：
Dondorp AM;Fairhurst RM;Slutsker L;Macarthur JR;Breman JG;Guerin PJ;Wellems TE;Ringwald P;Newman RD;Plowe CV
通讯作者：
Plowe CV
影响因子：
16
作者：
Fidock, DA;Nomura, T;Wellems, TE
通讯作者：
Wellems, TE
影响因子：
3.6
作者：
Mu, JB;Ferdig, MT;Su, XZ
通讯作者：
Su, XZ
影响因子：
56.3
作者：
Amaratunga, Chanaki;Sreng, Sokunthea;Suon, Seila;Phelps, Erika S.;Stepniewska, Kasia;Lim, Pharath;Zhou, Chongjun;Mao, Sivanna;Anderson, Jennifer M.;Lindegardh, Niklas;Jiang, Hongying;Song, Jianping;Su, Xin-zhuan;White, Nicholas J.;Dondorp, Arjen M.;Anderson, Tim J. C.;Fay, Michael P.;Mu, Jianbing;Duong, Socheat;Fairhurst, Rick M.
通讯作者：
Fairhurst, Rick M.