Size Changeable Nanocarriers with Nuclear Targeting for Effectively Overcoming Multidrug Resistance in Cancer Therapy
Size Changeable Nanocarriers with Nuclear Targeting for Effectively Overcoming Multidrug Resistance in Cancer Therapy
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DOI：
10.1002/adma.201502865
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发表时间：
2015-11-04
影响因子：
29.4
通讯作者：
Zhou, Shaobing
中科院分区：
文献类型：
--
作者：
Guo, Xing;Wei, Xiao;Zhou, Shaobing
一个大小可变的聚合物胶束系统与双壳，在酸性pH条件下，其大小增加，并改变为较小的胶束，触发细胞内谷胱甘肽（GSH），成功地开发。它能够将抗癌药物直接递送到多药耐药（MDR）肿瘤细胞的细胞核，以高效地对抗耐药乳腺癌。
A size changeable polymer micelle system with a dual shell, which increases in size under acidic pH conditions and is altered to smaller micelles, triggered by intracellular glutathione (GSH), is successfully developed. It is capable of direct delivering anticancer drugs to the nucleus of multidrug resistance (MDR) tumor cells for highly effective combating of drug resistant breast cancer.