Phenotype-dependent expression of cadherin 6B in vascular and visceral smooth muscle cells
Phenotype-dependent expression of cadherin 6B in vascular and visceral smooth muscle cells
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DOI：
10.1016/s0014-5793(00)01220-5
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发表时间：
2000-03-03
期刊：
影响因子：
3.5
通讯作者：
Sobue, K
中科院分区：
文献类型：
--
作者：
Chimori, Y;Hayashi, K;Sobue, K
我们使用mRNA消减分化和去分化平滑肌细胞（SMC），以揭示SMC的表型调制的分子机制。用这种方法，我们发现，一个10 kb的mRNA编码的同型细胞粘附分子，钙粘蛋白6B，强烈表达在分化的血管和内脏平滑肌细胞，但不是在去分化的平滑肌细胞来自他们。在体内，钙粘蛋白6B表达在血管和内脏SMC，除了脑，脊髓，视网膜和肾脏，在鸡胚胎发育的后期阶段。这些结果表明，钙粘蛋白6B是一种新的血管和内脏SMC表型的分子标记物，并参与了SMC的晚期分化。(C)2000年欧洲生物化学学会联合会。
We used mRNA subtraction of differentiated and dedifferentiated smooth muscle cells (SMCs) to reveal the molecular mechanisms underlying the phenotypic modulation of SMCs. With this approach, we found that a 10 kb mRNA encoding a homotypic cell adhesion molecule, cadherin 6B, was strongly expressed in differentiated vascular and visceral SMCs, but not in the dedifferentiated SMCs derived from them. In vivo, cadherin 6B was expressed in vascular and visceral SMCs, in addition to brain, spinal cord, retina and kidney, at a late stage of chicken embryonic development. These results suggest that cadherin 6B is a novel molecular marker for vascular and visceral SMC phenotypes and is involved in the late differentiation of SMCs. (C) 2000 Federation of European Biochemical Societies.