Understanding the Mechanism of Drug Transfer and Retention of Drug-Coated Balloons.
Understanding the Mechanism of Drug Transfer and Retention of Drug-Coated Balloons.
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DOI：
10.1177/10742484221119559
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发表时间：
2022-01
影响因子：
2.6
通讯作者：
Yazdani, Saami K.
中科院分区：
文献类型：
--
作者：
Villar-Matamoros, Estefanny;Stokes, Lauren;Lloret, Alyssa;Todd, Meagan;Tillman, Bryan W.;Yazdani, Saami K.
本研究旨在使用市售DCB确定不同充盈参数对紫杉醇输送和保留的影响。药物涂层球囊（DCB）已成为外周动脉疾病的标准治疗方法。临床数据表明，不同的DCB输送参数直接影响患者结局。递送参数的差异可能会改变DCB上药物涂层的保留。在离体脉动流生物反应器系统中使用收获的猪颈动脉。然后以1：1或1.25：1的DCB-动脉比展开DCB，充盈时间为30秒或1分钟，通过时间为30秒或3分钟。在DCB展开后1小时和1天，通过药代动力学分析评价动脉组织中的药物滞留量。与1小时通过时间为30秒相比，在1：1充盈比和3分钟通过时间下动脉紫杉醇水平较低（12.3 ± 1.6 ng/mg vs. 391 ± 139 ng/mg，P = 0.036）。在第1天，与1.25：1相比，以1：1的比例展开DCB导致药物滞留较少（61.3 ± 23.1 ng/mg vs. 404 ± 195 ng/mg，P = 0.013）。动脉紫杉醇滞留随着通过时间的延长和球囊的次优扩张而减少。优化输送参数可作为提高临床DCB结局的有效策略。
The purpose of this study was to determine the impact of varying inflation parameters on paclitaxel delivery and retention using a commercially available DCB. Drug-coated balloons (DCB) have become the standard treatment for peripheral artery disease. Clinical data suggest that varying DCB delivery parameters directly impact patient outcome. Differences in delivery parameters can potentially alter the retention of the drug coating on DCBs. Harvested porcine carotid arteries were utilized in an ex vivo pulsatile flow bioreactor system. The DCBs were then deployed at a DCB-to-artery ratio of 1:1 or 1.25:1, an inflation time of 30 seconds or 1 minute and transit time of 30 seconds or 3 minutes. The amount of drug retention in arterial tissue was evaluated by pharmacokinetic analysis at 1 hour and 1 day post DCB deployment. Arterial paclitaxel levels were found to be less at an inflation ratio of 1:1 with 3-minute transit time as compared to 30 seconds of transit time at 1 hour (12.3 ± 1.6 ng/mg vs. 391 ± 139 ng/mg, P = .036). At 1-day, DCBs deployed at a ratio of 1:1 resulted in less drug retention as compared to 1.25:1 (61.3 ± 23.1 ng/mg vs. 404 ± 195 ng/mg, P = .013). Arterial paclitaxel retention is reduced with extended transit times and sub-optimal expansion of the balloon. Optimization of delivery parameters can serve as an effective strategy to enhance clinical DCB outcomes.
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影响因子：
2.3
作者：
Li, Yan;Tellez, Armando;Granada, Juan F.
通讯作者：
Granada, Juan F.
DOI：
10.52586/s560
发表时间：
2021-12-03
期刊：
Frontiers in bioscience (Scholar edition)
影响因子：
--
作者：
Shi, Richard;Babu, Sateesh
通讯作者：
Babu, Sateesh
影响因子：
4.6
作者：
Goel, Emily;Erwin, Megan;Yazdani, Saami K.
通讯作者：
Yazdani, Saami K.
影响因子：
6.7
作者：
Cremers, Bodo;Speck, Ulrich;Scheller, Bruno
通讯作者：
Scheller, Bruno
影响因子：
11.3
作者：
Buszman, Piotr P.;Tellez, Armando;Granada, Juan F.
通讯作者：
Granada, Juan F.