Primary Follicular Lymphoma of the Testis and Epididymis in Adults
Primary Follicular Lymphoma of the Testis and Epididymis in Adults
复制标题
成人睾丸和附睾原发性滤泡性淋巴瘤
DOI：
--
复制
发表时间：
2007
影响因子：
5.6
通讯作者：
A. Dogan
中科院分区：
文献类型：
--
作者：
C. Bacon;H. Ye;T. Diss;C. Mcnamara;B. Kueck;R. Hasserjian;A. Rohatiner;J. Ferry;M. Du;A. Dogan
原发性睾丸淋巴瘤通常发生在 60 岁以上的患者中。大多数是弥漫性大B细胞淋巴瘤，播散频繁，预后不良。成人睾丸的原发性滤泡性淋巴瘤尚未得到很好的表征。然而，最近在儿童中发现了少数原发性睾丸滤泡淋巴瘤。这些结果显示 1E 期疾病，缺乏 BCL2 基因重排和 Bcl-2 蛋白表达，并且临床结果良好。在此，我们描述 5 例成人睾丸和附睾原发性滤泡性淋巴瘤病例。这些表现为直径 12 至 40 毫米的单侧睾丸肿块，组织学特征为硬化背景中的小肿瘤滤泡。肿瘤细胞表达CD10和Bcl-6，但不表达Bcl-2，并且缺乏t(14;18)(q32;q21)/IGH-BCL2和BCL6基因重排。 5 名患者中有 4 名年龄不超过 35 岁，其中 4 名患者患有 1 期 EA 疾病。尽管 5 名患者中有 2 名的随访时间为 12 个月或更短，但迄今为止，每名患者均遵循惰性临床过程。这些特征与大多数成人结节性滤泡性淋巴瘤不同，但与儿童原发性睾丸滤泡性淋巴瘤非常相似。总之，儿科和成人病例代表了睾丸和附睾的 t(14;18)(q32;q21)/IGH-BCL2 阴性原发性滤泡性淋巴瘤的独立临床病理实体，通常在年轻男性中表现为临床惰性局部疾病，应与老年人睾丸中更常见的弥漫性大 B 细胞淋巴瘤相鉴别。
Primary testicular lymphomas typically occur in patients over 60 years of age. Most are diffuse large B-cell lymphomas with frequent dissemination and a poor prognosis. Primary follicular lymphoma of the adult testis has not been well characterized. However, a small number of primary testicular follicular lymphomas have recently been described in children. These showed stage 1E disease, a lack of BCL2 gene rearrangement and Bcl-2 protein expression, and a good clinical outcome. Here, we describe 5 cases of primary follicular lymphoma of the testis and epididymis in adults. These presented as unilateral testicular masses 12 to 40 mm in diameter and were characterized histologically by small neoplastic follicles in a sclerotic background. The neoplastic cells expressed CD10 and Bcl-6, but not Bcl-2 and lacked t(14;18)(q32;q21)/IGH-BCL2 and BCL6 gene rearrangements. Four of the five patients were 35 years old or younger, and 4 presented with stage 1EA disease. Although follow-up is 12 months or less in 2 of the 5 patients, to date each has followed an indolent clinical course. These features are different from those of most adult nodal follicular lymphomas but are very similar to those of the pediatric primary testicular follicular lymphomas. Together, the pediatric and adult cases represent a discrete clinicopathologic entity of t(14;18)(q32;q21)/IGH-BCL2-negative primary follicular lymphoma of the testis and epididymis, which typically present as clinically indolent localized disease in young males and should be distinguished from the diffuse large B-cell lymphoma more frequently seen in the testes of older adults.
影响因子：
20.3
作者：
Lorsbach, RB;Shay-Seymore, D;Behm, FG
通讯作者：
Behm, FG
影响因子：
20.3
作者：
F. Coco;G. Gaidano;Diane;Louie;K. Offit;R. Chaganti;R. Dalla-Favera
通讯作者：
F. Coco;G. Gaidano;Diane;Louie;K. Offit;R. Chaganti;R. Dalla-Favera
组织学不常见的儿童恶性非霍奇金淋巴瘤。
影响因子：
11.4
作者：
Ribeiro,RC;Pui,CH;Murphy,SB;Shuster,JJ;Hvizdala,EV;Falletta,J;Link,MP;Sullivan,MP;Pick,TE;Sandlund,JT
通讯作者：
Sandlund,JT