Solid-state cross-coupling reactions of insoluble aryl halides under polymer-assisted grinding conditions
Solid-state cross-coupling reactions of insoluble aryl halides under polymer-assisted grinding conditions
复制标题
聚合物辅助研磨条件下不溶性芳基卤化物的固态交叉偶联反应
DOI：
10.1039/d2fd00121g
复制
发表时间：
2023
影响因子：
3.4
通讯作者：
Ito Hajime
中科院分区：
文献类型：
--
作者：
Kubota Koji;Seo Tamae;Ito Hajime
在本研究中，聚合物辅助研磨（POLAG）是一种基于使用聚合物添加剂的球磨技术，应用于不溶性芳基卤化物的机械化学固态铃木-宫浦交叉偶联反应。我们发现，通过在高温球磨条件下添加聚四氟乙烯 (PTFE) 作为 POLAG 添加剂，可以提高这种具有挑战性的固态交叉耦合的效率。我们的结果表明，POLAG 是一种很有前途的方法，用于控制在传统溶液条件下几乎不反应的不溶性底物的反应性。
In this study, polymer-assisted grinding (POLAG), a ball-milling technique based on the use of polymer additives, was applied to mechanochemical solid-state Suzuki–Miyaura cross-coupling reactions of insoluble aryl halides. We found that the efficiency of this challenging solid-state cross-coupling was improved by the addition of polytetrafluoroethylene (PTFE) as a POLAG additive under high-temperature ball-milling conditions. Our results suggest that POLAG is a promising approach for controlling the reactivity of insoluble substrates that are barely reactive under conventional solution-based conditions.