Infrared neural stimulation of human spinal nerve roots in vivo
Infrared neural stimulation of human spinal nerve roots in vivo
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DOI：
10.1117/1.nph.2.1.015007
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发表时间：
2015-01-01
期刊：
影响因子：
5.3
通讯作者：
Mahadevan-Jansen, Anita
中科院分区：
文献类型：
--
作者：
Cayce, Jonathan M.;Wells, Jonathon D.;Mahadevan-Jansen, Anita
红外神经刺激（INS）是一种神经刺激模式，使用脉冲红外光通过非接触式接口唤起无伪影、空间精确的神经活动;然而，该技术尚未在人体中得到证实。本研究旨在证明INS在人体内的安全性和有效性。在接受选择性背根切断术的患者（n = 7）中评估了INS在人体中的可行性，其中在每个神经的两到三个部位上用INS在体内刺激确定用于横断的活动过度的背根，并在整个刺激过程中获得肌电图记录。去除刺激的背根，进行组织学检查以确定INS的热损伤阈值。在0.53和1.23 J/cm（2）的辐射暴露下，63%的人背根神经发生阈值激活。在所有情况下，只有一个或两个监测的肌肉群被激活的INS刺激的过度活跃的脊神经根确定的电刺激。在1.09 J/cm（2）时首次观察到热损伤，并确定了2：1的安全比。这些发现证明了INS作为激活体内人体神经的新方法的成功，并提供了追求INS在人体中临床驱动的治疗和诊断应用所需的必要安全性数据。(C)2015年，美国光电仪器工程师学会（SPIE）
Infrared neural stimulation (INS) is a neurostimulation modality that uses pulsed infrared light to evoke artifact-free, spatially precise neural activity with a noncontact interface; however, the technique has not been demonstrated in humans. The objective of this study is to demonstrate the safety and efficacy of INS in humans in vivo. The feasibility of INS in humans was assessed in patients (n = 7) undergoing selective dorsal root rhizotomy, where hyperactive dorsal roots, identified for transection, were stimulated in vivo with INS on two to three sites per nerve with electromyogram recordings acquired throughout the stimulation. The stimulated dorsal root was removed and histology was performed to determine thermal damage thresholds of INS. Threshold activation of human dorsal rootlets occurred in 63% of nerves for radiant exposures between 0.53 and 1.23 J/cm(2). In all cases, only one or two monitored muscle groups were activated from INS stimulation of a hyperactive spinal root identified by electrical stimulation. Thermal damage was first noted at 1.09 J/cm(2) and a 2: 1 safety ratio was identified. These findings demonstrate the success of INS as a fresh approach for activating human nerves in vivo and providing the necessary safety data needed to pursue clinically driven therapeutic and diagnostic applications of INS in humans. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)