Cisplatin-conjugated gold nanoparticles as a theranostic agent for head and neck cancer
Cisplatin-conjugated gold nanoparticles as a theranostic agent for head and neck cancer
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DOI：
10.1002/hed.24935
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发表时间：
2018-01-01
影响因子：
2.9
通讯作者：
Popovtzer, Rachela
中科院分区：
文献类型：
--
作者：
Davidi, Erez Shmuel;Dreifuss, Tamar;Popovtzer, Rachela
背景本研究的目的是开发一种纳米平台，同时作为头颈癌的放射增敏剂、药物载体和肿瘤显像剂。方法合成了20 nm的葡萄糖和顺铂包被的金纳米颗粒（CG-GNPs）。在体外评估了它们对肿瘤细胞的渗透及其细胞毒性。进行体内实验以评估它们对肿瘤生长的影响及其成像能力。结果CG-GNPs 显示出对肿瘤细胞的有效渗透和与单独的顺铂相似的细胞毒性。与单独放疗和游离顺铂放疗相比，CG-GNP 与放疗相结合可实现更大的肿瘤缩小效果。 CG-GNPs还表现出高效的肿瘤成像能力。结论我们的CG-GNPs在增强抗肿瘤作用、克服对化疗和放疗的耐药性以及允许成像引导治疗方面具有巨大的潜力。
BackgroundThe purpose of this study was to develop a nanoplatform, which simultaneously acts as radiosensitizer, drug carrier, and tumor imaging agent for head and neck cancer.MethodsWe synthesized 20 nm gold nanoparticles, coated with glucose and cisplatin (CG-GNPs). Their penetration into tumor cells and their cellular toxicity were evaluated in vitro. In vivo experiments were conducted to evaluate their impact on tumor growth and their imaging capabilities.ResultsThe CG-GNPs showed efficient penetration into tumor cells and similar cellular toxicity as cisplatin alone. Combined with radiation, CG-GNPs led to greater tumor reduction than that of radiation alone and radiation with free cisplatin. The CG-GNPs also demonstrated efficient tumor imaging capabilities.ConclusionOur CG-GNPs have a great potential to increase antitumor effect, overcome resistance to chemotherapeutics and radiation, and allow imaging-guided therapy.