Hypersensitivity Pneumonitis and Related Conditions in the Work Environment
Hypersensitivity Pneumonitis and Related Conditions in the Work Environment
复制标题
DOI：
10.1016/j.iac.2011.07.004
复制
发表时间：
2011-11-01
影响因子：
2.6
通讯作者：
Fink, Jordan N.
中科院分区：
文献类型：
--
作者：
Zacharisen, Michael C.;Fink, Jordan N.
过敏性肺炎可发生于各种各样的职业暴露。虽然不常见且难以识别，但通过详细的工作接触史、体格检查、放射照相、肺功能研究以及使用血清和支气管肺泡灌洗液的选定实验室研究，可以早期识别工人，以避免抗原，并在必要时进行药物治疗。肺活检可能是必要的，以排除其他间质性肺病。尽管有各种有机抗原触发，但急性、亚急性或慢性形式的表现相似。全身性皮质类固醇是唯一可靠的药物治疗，但不改变长期结果。
Hypersensitivity pneumonitis can occur from a wide variety of occupational exposures. Although uncommon and difficult to recognize, through a detailed work exposure history, physical examination, radiography, pulmonary function studies, and selected laboratory studies using sera and bronchoalveolar lavage fluid, workers can be identified early to effect avoidance of the antigen and institute pharmacologic therapy, if necessary. A lung biopsy may be necessary to rule out other interstitial lung diseases. Despite the varied organic antigen triggers, the presentation is similar with acute, subacute, or chronic forms. Systemic corticosteroids are the only reliable pharmacologic treatment but do not alter the long-term outcome.