Bone voyage: An expedition into the molecular and cellular parameters affecting bone graft fate
Bone voyage: An expedition into the molecular and cellular parameters affecting bone graft fate
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DOI：
10.1016/j.bone.2007.06.023
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发表时间：
2007-10-01
期刊：
影响因子：
4.1
通讯作者：
Leucht, P.
中科院分区：
文献类型：
--
作者：
Helms, J. A.;Amasha, R. R.;Leucht, P.
骨科和颅面外科对骨移植的需求正在稳步增长。据估计，在美国，每年约有50万例包括植骨在内的手术，其中大多数采用了自体植骨。这一视角主要关注在这种骨移植的骨整合过程中发生的生物学事件。在这里，移植骨结合的三个关键因素-胚胎起源、骨骼祖细胞的包含和受体部位的完整性-进行了讨论。总而言之，它们构成了植骨存活的基础，并最终获得了积极的临床结果。(C)2007 Elsevier Inc.保留所有权利。
The demand for bone grafts in orthopaedic and craniofacial surgery is steadily increasing. Estimations suggest that about 500,000 are performed annually in the United States that include bone grafting as a component of the surgery, and the majority of these surgeries employ autografts. This perspective focuses on the biological events that occur during osseointegration of such bone grafts. Here, three key factors of graft osseointegration - the embryonic origin, the inclusion of skeletal progenitor cells, and the integrity of the recipient site - are discussed. Altogether, they form the foundation for survival of the bone graft and eventually for a positive clinical outcome of the procedure. (C) 2007 Elsevier Inc. All rights reserved.