Clinical application of dipole models in the localization of epileptiform activity
Clinical application of dipole models in the localization of epileptiform activity
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DOI：
10.1097/wnp.0b013e31803ece13
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发表时间：
2007-04-01
影响因子：
2.4
通讯作者：
Hawes-Ebersole, Susan
中科院分区：
文献类型：
--
作者：
Ebersole, John S.;Hawes-Ebersole, Susan
常规临床解释脑电图使用视觉检查的痕迹是一个历史悠久，但简单的分析形式。在试图通过EEG尖峰或癫痫发作波形定位致痫灶时尤其如此。对这些电位的皮层基底的进一步了解使我们能够通过头皮电压场的时空分析来确定它们可能的大脑起源。等效偶极子建模就是这样一种技术。虽然是一个不完美的尖峰或癫痫发作源的代表，偶极子模型的正确解释可以导致更好地表征其定位和传播。现代三维MRI重建技术和逼真的头部模型都提高了定位精度，并提供了一种手段，显示结果的图像中的个人的大脑。
Routine clinical interpretation of EEG using visual inspection of traces is a time-honored, but simplistic, form of analysis. This is particularly true in attempts to localize an epileptogenic focus by means of EEG spike or seizure waveforms. Improved understanding of the cortical substrates of these potentials has allowed us to identify their likely cerebral origins through spatio-temporal analysis of scalp voltage fields. Equivalent dipole modeling is one such technique. Although an imperfect representation of spike or seizure sources, proper interpretation of dipole models can lead to a far better characterization of their localization and propagation. Modem techniques of 3-D MRI reconstruction and realistic head models have both improved localization accuracy and provided a means of displaying results in an image of the individual's brain.