Realistic wave-optics simulation of X-ray phase-contrast imaging at a human scale.
Realistic wave-optics simulation of X-ray phase-contrast imaging at a human scale.
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DOI：
10.1038/srep12011
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发表时间：
2015-07-14
影响因子：
4.6
通讯作者：
Gupta R
中科院分区：
文献类型：
--
作者：
Sung Y;Segars WP;Pan A;Ando M;Sheppard CJ;Gupta R
X 射线相衬成像 (XPCI) 可以显着提高 X 射线医学成像中的软组织对比度。尽管全世界都在努力开发新型 XPCI 系统，但目前还没有一个能够严格预测人体规模临床 XPCI 系统性能的数值框架。我们开发了这样一种工具，将用非均匀有理 B 样条 (NURBS) 定义的数值拟人体模与基于波动光学的模拟器相结合，该模拟器可以准确捕获来自人体比例数值模体的相位对比信号。使用基于同步加速器的高性能 XPCI 系统，我们提供模拟图像和实验图像之间的定性比较。我们的工具可用于模拟 XPCI 在各种疾病实体上的性能，并以公正的方式比较所提出的 XPCI 系统。
X-ray phase-contrast imaging (XPCI) can dramatically improve soft tissue contrast in X-ray medical imaging. Despite worldwide efforts to develop novel XPCI systems, a numerical framework to rigorously predict the performance of a clinical XPCI system at a human scale is not yet available. We have developed such a tool by combining a numerical anthropomorphic phantom defined with non-uniform rational B-splines (NURBS) and a wave optics-based simulator that can accurately capture the phase-contrast signal from a human-scaled numerical phantom. Using a synchrotron-based, high-performance XPCI system, we provide qualitative comparison between simulated and experimental images. Our tool can be used to simulate the performance of XPCI on various disease entities and compare proposed XPCI systems in an unbiased manner.