Anxiety- and depression-like behaviors are accompanied by an increase in oxidative stress in a rat model of fetal alcohol spectrum disorders: Protective effects of voluntary physical exercise
Anxiety- and depression-like behaviors are accompanied by an increase in oxidative stress in a rat model of fetal alcohol spectrum disorders: Protective effects of voluntary physical exercise
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DOI：
10.1016/j.neuropharm.2011.10.006
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发表时间：
2012-03-01
影响因子：
4.7
通讯作者：
Christie, Brian R.
中科院分区：
文献类型：
--
作者：
Brocardo, Patricia S.;Boehme, Fanny;Christie, Brian R.
产前酒精暴露会损害发育中的神经系统，对大脑结构和功能造成长期损害。在这项研究中，我们分析了在大脑发育期间暴露于这种致畸剂如何影响大脑中的细胞内氧化还原状态以及焦虑和抑郁样表型的发展。此外，我们还测试了有氧运动是否可能通过增加神经元抗氧化能力和/或减轻乙醇诱导的行为缺陷对胎儿酒精谱系障碍（FASD）具有治疗潜力。Sprague-Dawley大鼠在所有三个月当量中施用乙醇（即，在整个妊娠期和出生后的前10天）。在出生后第48天（PND），将暴露于乙醇的动物和对照动物分配到久坐组或跑步组。跑步者可以自由使用跑步轮12天，并在PND 60时评估焦虑和抑郁样行为。围产期乙醇暴露导致成年大鼠抑郁和焦虑样行为的发生，而不影响其自发活动。自愿轮运行扭转了抑郁样行为在乙醇暴露的男性，但不是在乙醇暴露的女性。乙醇暴露大鼠海马和小脑的脂质过氧化和蛋白质氧化水平显著增加，内源性抗氧化剂谷胱甘肽水平随之降低。自愿运动能够扭转赤字谷胱甘肽在乙醇暴露的男性和女性。因此，虽然自愿体育锻炼增加谷胱甘肽水平在两种性别，其影响在行为水平上是性别依赖性的，只有乙醇暴露的男性跑步者表现出抑郁样行为的减少。(c)2011爱思唯尔有限公司保留所有权利。
Prenatal ethanol exposure can damage the developing nervous system, producing long-lasting impairments in both brain structure and function. In this study we analyzed how exposure to this teratogen during the period of brain development affects the intracellular redox state in the brain as well as the development of anxiety- and depressive-like phenotypes. Furthermore, we also tested whether aerobic exercise might have therapeutic potential for fetal alcohol spectrum disorders (FASD) by increasing neuronal antioxidant capacity and/or by alleviating ethanol-induced behavioral deficits. Sprague-Dawley rats were administered ethanol across all three-trimester equivalents (i.e., throughout gestation and during the first 10 days of postnatal life). Ethanol-exposed and control animals were assigned to either sedentary or running groups at p ostnatal day (PND) 48. Runners had free access to a running wheel for 12 days and at PND 60 anxiety- and depressive-like behaviors were assessed. Perinatal ethanol exposure resulted in the occurrence of depressive and anxiety-like behaviors in adult rats without affecting their locomotor activity. Voluntary wheel running reversed the depressive-like behaviors in ethanol-exposed males, but not in ethanol-exposed females. Levels of lipid peroxidation and protein oxidation were significantly increased in the hippocampus and cerebellum of ethanol-exposed rats, and there was a concomitant reduction in the levels of the endogenous antioxidant glutathione. Voluntary exercise was able to reverse the deficits in glutathione both in ethanol-exposed males and females. Thus, while voluntary physical exercise increased glutathione levels in both sexes, its effects at the behavioral level were sex dependent, with only ethanol-exposed male runners showing a decrease in depressive-like behaviors. (c) 2011 Elsevier Ltd. All rights reserved.