Three-dimensional models of individual cardiac histoanatomy: Tools and challenges
Three-dimensional models of individual cardiac histoanatomy: Tools and challenges
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DOI：
10.1196/annals.1380.023
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Kohl, Peter
中科院分区：
文献类型：
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作者：
Burton, Rebecca A. B.;Plank, Gernot;Kohl, Peter
有一个需要，并在实用程序中，心脏组织解剖学的数据集的采集，重建个人的心脏的基础上的非侵入性成像，如MRI的视觉，丰富的参考系列组织学的详细图集从代表性的样品。这些数据集将是有用的，不仅作为一个知识库的具体心脏组织解剖学，但可以形成的基础上生成个性化的高分辨率心脏结构-功能模型。目前的文章提出了一个步骤，在这个大方向：它说明了如何全心脏无创成像可以与全心脏组织学相结合的方法，以实现自动化建设的组织解剖学详细模型的心脏三维结构和功能，在迄今为止前所未有的分辨率和精度（基于26.4 × 26.4 × 24.4 μ m的MRI体素大小，并丰富了组织学细节）。它概述了在这一探索中使用的工具，并根据可能受益于这些数据和工具的应用情况，概述了这一方法带来的挑战。
There is a need for, and utility in, the acquisition of data sets of cardiac histoanatomy, with the vision of reconstructing individual hearts on the basis of noninvasive imaging, such as MRI, enriched by reference to detailed atlases of serial histology obtained from representative samples. These data sets would be useful not only as a repository of knowledge regarding the specifics of cardiac histoanatomy, but could form the basis for generation of individualized high-resolution cardiac structure-function models. The current article presents a step in this general direction: it illustrates how whole-heart noninvasive imaging can be combined with whole-heart histology in an approach to achieve automated construction of histoanatomically detailed models of cardiac 3D structure and function at hitherto unprecedented resolution and accuracy (based on 26.4 x 26.4 x 24.4 mu m MRI voxel size, and enriched by histological detail). It provides an overview of the tools used in this quest and outlines challenges posed by the approach in the light of applications that may benefit from the availability of such data and tools.