Tissue plasminogen activator: comparison of dose and route of administration in a rabbit model of thromboembolic stroke.
Tissue plasminogen activator: comparison of dose and route of administration in a rabbit model of thromboembolic stroke.
复制标题
组织纤溶酶原激活剂：血栓栓塞性中风兔模型中剂量和给药途径的比较。
DOI：
10.1080/01616412.1993.11740173
复制
发表时间：
1993
影响因子：
1.9
通讯作者：
Gross,CE
中科院分区：
文献类型：
--
作者：
Bednar,MM;Raymond,SJ;Gross,CE
在血栓栓塞性中风的兔模型中，使用两种不同浓度（3、5和10 mg/kg; 20%推注，其余80%在30分钟内给药）评价组织纤溶酶原激活剂的血栓溶解活性。和给药途径（静脉内与局部动脉内）。通过颈动脉将自体锡标记凝块栓塞到大脑。然后以注明的剂量和途径给予组织纤溶酶原激活剂（所有组n = 3）。溶栓活性之后，在4小时内对含锡凝块进行连续X射线检查。然后取出大脑并进行肉眼检查。在所有动物中，仅静脉内给予5 mg/kg组织纤溶酶原激活剂可产生大于50%的凝块溶解。高于（10 mg/kg）或低于（3 mg/kg）的t-PA剂量在产生血栓溶解方面效果较差，表明每组中仅一只动物的血栓溶解大于50%。我们的结论是，在血栓栓塞性中风模型中，组织型纤溶酶原激活剂静脉给药比动脉内给药更有效，最佳剂量为5 mg/kg。[神经学研究1993;15：405-408]
The thrombolytic activity of tissue plasminogen activator was evaluated in a rabbit model of thromboembolic stroke using both various concentrations (3, 5, and 10 mg/kg; 20% bolus with the remaining 80% given over 30 min.) and routes of administration (intravenous versus regional intra-arterial). An autologous tin-tagged clot was embolized to the brain via the carotid artery. Tissue plasminogen activator was then given at the doses and routes noted (n = 3 in all groups). Thrombolytic activity was followed by serial x-rays of the tin-laden clot over a four-hour period. The brains were then removed and subjected to gross inspection. Only the intravenous dose of 5 mg/kg tissue plasminogen activator produced greater than 50% clot lysis in all animals. Doses of t-PA higher (10 mg/kg) or lower (3 mg/kg) than this were less effective in producing thrombolysis, demonstrating greater than 50% clot lysis in only one animal of each group. We conclude that in this model of thromboembolic stroke the intravenous administration of tissue plasminogen activator is more effective than intra-arterialand that the optimal dose is in the range of 5 mg/kg. [Neurol Res 1993;15: 405-408]