Trial Forge Guidance 1: what is a Study Within A Trial (SWAT)?
Trial Forge Guidance 1: what is a Study Within A Trial (SWAT)?
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DOI：
10.1186/s13063-018-2535-5
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发表时间：
2018-02-23
期刊：
影响因子：
2.5
通讯作者：
Williamson, Paula R.
中科院分区：
文献类型：
--
作者：
Treweek, Shaun;Bevan, Simon;Williamson, Paula R.
随机试验是所有循证医疗保健系统的核心组成部分，来自它们的证据有助于支持医疗保健用户，卫生专业人员和其他人做出更明智的治疗决定。然而，可供试验者用于支持随机试验设计、实施和报告决策的证据很少。Trial Forge是一项旨在为审判决策增加证据基础的举措，并在此过程中提高审判效率。填补证据空白的一种方法是运行试验中的研究，或SWAT。本指导文件提供了SWAT的简要定义，解释了为什么它们很重要，以及一些来自现有SWAT经验的实用“顶级技巧”。我们希望该指南将有助于试验者、方法学家、资助者、审批机构和其他人明确什么是SWAT，以及做一个SWAT需要做什么。
Randomised trials are a central component of all evidence-informed health care systems and the evidence coming from them helps to support health care users, health professionals and others to make more informed decisions about treatment. The evidence available to trialists to support decisions on design, conduct and reporting of randomised trials is, however, sparse. Trial Forge is an initiative that aims to increase the evidence base for trial decision-making and in doing so, to improve trial efficiency.One way to fill gaps in evidence is to run Studies Within A Trial, or SWATs. This guidance document provides a brief definition of SWATs, an explanation of why they are important and some practical 'top tips' that come from existing experience of doing SWATs. We hope the guidance will be useful to trialists, methodologists, funders, approvals agencies and others in making clear what a SWAT is, as well as what is involved in doing one.