The molecular hug between the ER and the mitochondria
The molecular hug between the ER and the mitochondria
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DOI：
10.1016/j.ceb.2013.02.010
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发表时间：
2013-08-01
影响因子：
7.5
通讯作者：
Kornmann, Benoit
中科院分区：
文献类型：
--
作者：
Kornmann, Benoit
细胞器的一个长期观察到但经常被忽视的特性是它们结合成连接点的能力。细胞生理学的各个方面似乎越来越依赖于这些接触位点，因为它们的中心分子组分正在被鉴定。内质网（ER）和线粒体之间的接触位点正在成为这种接触的一个主要例子。这些接触位点的生理作用，首先被认为是有限的两个细胞器之间的脂质和钙交换的便利，被发现扩展到线粒体和ER功能的意想不到的方面。
A long-observed but often neglected property of cellular organelles is their ability to associate into junctions. Aspects of cell physiology appear more and more to depend upon these contact sites, as their central molecular components are being identified. Contact sites between the endoplasmic reticulum (ER) and the mitochondria are emerging as a prime example of such contacts. The physiological role of these contact sites, first thought to be limited to the facilitation of lipid and calcium exchange between the two organelles, is found to extend to unexpected aspects of mitochondria and ER functions.