Astrocyte cytolysis by MHC class II-specific mouse T cell clones.
Astrocyte cytolysis by MHC class II-specific mouse T cell clones.
复制标题
MHC II 类特异性小鼠 T 细胞克隆对星形胶质细胞进行细胞溶解。
DOI：
10.1097/00007890-199308000-00028
复制
发表时间：
1993
期刊：
影响因子：
6.2
通讯作者：
Lancki,DW
中科院分区：
文献类型：
--
作者：
Reder,AT;Lascola,CD;Flanders,SA;Maimone,D;Jensen,MA;Skias,DD;Lancki,DW
The brain is “immunologically privileged,” in part because class I and II MHC antigens are not normally present on glia or neurons. However, under certain conditions such as transplantation, glial cells express MHC proteins at levels sufficient for glia to become targets of immune responses. Cultured astrocytes expressing very low levels of MHC class I protein are killed efficiently by MHC class I antigen-specific CTL. Mouse brain allografts, however, are rejected by CD4+ T cells that are likely to be class II MHC-specific. The level of expression of MHC class II antigen needed to trigger specific killing of astrocytes by CD4+ T cells, independent of exogenous antigen, has not been studied.
