Direct Aniline Formation with Benzene and Hydroxylamine
Direct Aniline Formation with Benzene and Hydroxylamine
复制标题
DOI：
10.3390/chemistry5040139
复制
发表时间：
2023-09
期刊：
影响因子：
--
通讯作者：
Ningyu Liu;Matthew D. Sleck;W. Jones
中科院分区：
文献类型：
--
作者：
Ningyu Liu;Matthew D. Sleck;W. Jones
考察了苯胺形成的一步法。以钒酸盐为催化剂，氧化铁为助催化剂，盐酸羟胺为胺源，苯胺的收率可达90%以上，选择性高。进一步的研究表明，整个反应是伪二级的羟胺浓度。区域选择性H-D交换实验表明，C-N键形成步骤通过不可逆亲电途径发生。基于所有的关键观察，提出了一种机制。
A single-step method for aniline formation was examined. Using a vanadate catalyst with an iron oxide co-catalyst and hydroxylamine hydrochloride as the amine source, an up to 90% yield of aniline was obtained with high selectivity. Further study showed that the overall reaction was pseudo-second order in terms of hydroxylamine concentration. Regioselective H-D exchange experiments suggest that the C-N bond formation step occurs via an irreversible electrophilic pathway. Based on all of the key observations, a mechanism is proposed.