Schizophrenia as a long-term outcome of pregnancy, delivery, and perinatal complications: A 28-year follow-up of the 1966 North Finland general population birth cohort
Schizophrenia as a long-term outcome of pregnancy, delivery, and perinatal complications: A 28-year follow-up of the 1966 North Finland general population birth cohort
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DOI：
10.1176/ajp.155.3.355
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发表时间：
1998-03-01
影响因子：
17.7
通讯作者：
Sipila, P
中科院分区：
文献类型：
--
作者：
Jones, PB;Rantakallio, P;Sipila, P
目的：1966年芬兰北部一般人群出生队列研究，以确定是否异常在怀孕期间，分娩，和新生儿期与成人发病的精神分裂症，方法：作者包括所有11,017例受试者在芬兰16岁时活着。对于每个人来说，在怀孕、分娩和婴儿期进行的标准化评估与覆盖28岁以下的国家精神病病例登记册相关联。DSM-III-R精神分裂症的受试者是通过两阶段筛选确定的，包括仔细阅读个人病例记录。计算了精神分裂症与特定妊娠、分娩和新生儿特征之间的关联（校正比值比）。结果：在这一队列中，76例DSM-III-R精神分裂症患者在28岁时发病，其中51例（67.1%）为男性。在病例组和未受影响的对照组中，母亲的人口统计学特征和以前的产科史相似，尽管前者在怀孕期间比平时更有可能患上抑郁症。低出生体重（
Objective: The 1966 North Finland general population birth cohort was studied to determine whether abnormalities during pregnancy, delivery, and the neonatal period are associated with adult-onset schizophrenia, Method: The authors included all 11,017 subjects alive in Finland at age 16. For each individual, standardized assessments made during pregnancy, delivery, and infancy were linked to national psychiatric case registers covering the period up to age 28. Subjects with DSM-III-R schizophrenia were identified by using a two-stage screen that included perusal of individual case records. Associations (adjusted odds ratios) between schizophrenia and specific pregnancy, delivery, and neonatal characteristics were calculated. Results: Within this cohort, 76 cases of DSM-III-R schizophrenia arose by age 28 years; 51 (67.1%) of these persons were men. Demographic characteristics and previous obstetric histories of the mothers were similar in the case and unaffected comparison groups, although the former were more likely to have been move depressed than usual during pregnancy. Low birth weight (