Evidence of rapid ongoing brain development beyond 2 years of age detected by fiber tracking
Evidence of rapid ongoing brain development beyond 2 years of age detected by fiber tracking
复制标题
DOI：
10.3174/ajnr.a1097
复制
发表时间：
2008-08-01
影响因子：
3.5
通讯作者：
Fiehler, J.
中科院分区：
文献类型：
--
作者：
Ding, X-Q.;Sun, Y.;Fiehler, J.
背景和目的：胼胝体纤维的发育对心理和认知功能具有重要意义。材料与方法：对55例年龄在0.2 ~ 39岁的健康人进行了胼胝体（corpus callosum，CC）的弥散张量成像（diffusion tensor imaging，DTI），并对CC的前、压部（gCC和sCC）的T2和FA值进行了定量测量。纤维跟踪，体积测定，和纤维密度计算的CC有关的年龄。配对t检验被用于显着差异的值在gCC和sCC.Results：T2弛豫时间在gCC和sCC下降快，在生命的第一个月，2岁后很少。FAgCC增加，直到5岁，此后保持几乎不变;它显示了显着增加，从0到2岁与2-5岁，而在其他年龄组没有差异。FAsCC值在2岁后没有显着变化。CC的纤维密度表现出逆年龄依赖性的趋势，从儿童到adulted.CONCLUSION：快速进行的变化，在大脑成熟（增加FAgCC）是可检测到的，直到5岁。DTI比T2弛豫技术揭示更多的脑成熟信息。
BACKGROUND AND PURPOSE: Development of callosal fibers is important for psychomotor and cognitive functions. We hypothesized that brain maturation changes are detectable beyond 2 years of age by using diffusion tensor imaging (DTI) of the corpus callosum (CC).MATERIALS AND METHODS: T2 and fractional anisotropy (FA) maps of the brain of 55 healthy subjects between 0.2 and 39 years of age were obtained, Quantitative T2 and FA values were measured at the genu and splenium of the CC (gCC and sCC). Fiber tracking, volumetric determination, and the fiber density calculations of the CC were related to age. A paired t test was used for significant differences between the values at the gCC and sCC.RESULTS: T2 relaxation times at gCC and sCC decrease fast in the first months of life and very little after 2 years of age. The FAgCC increases until 5 years of age and remains nearly constant thereafter; it showed a significant increase from 0 to 2 years versus 2-5 years, whereas there was no difference in the other age groups. FAsCC values showed no significant changes after 2 years of age. The fiber density of the CC shows a tendency of inverse age dependence from childhood to adulthood.CONCLUSION: Rapid ongoing changes in brain maturation (increase in FAgCC) are detectable until 5 years of age. DTI reveals more information about brain maturation than T2 relaxometry.