THE SENSORY EFFECTS OF L-MENTHOL ON HUMAN SKIN
THE SENSORY EFFECTS OF L-MENTHOL ON HUMAN SKIN
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DOI：
10.3109/08990229209144774
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发表时间：
1992-01-01
影响因子：
0.9
通讯作者：
GREEN, BG
中科院分区：
文献类型：
--
作者：
GREEN, BG
心理物理学测量的感觉效果的l-薄荷醇局部应用于前臂在受控的热条件下。在第一个实验中，受试者判断在薄荷醇或溶剂存在下加热或冷却皮肤所产生的感觉的强度和质量。在冷却过程中，薄荷醇增强了皮肤感觉，增加了燃烧的报告。在升温过程中，薄荷醇在低温下短暂地增强了感觉，在高温下持久地减弱了感觉;燃烧的报告频率随强度而变化。第二个实验测试了薄荷醇会降低温暖阈值和提高热痛阈值的假设。两个阈值均未观察到变化。因此，l-薄荷醇对有毛皮肤的主要感觉效果是提高凉爽的感觉并减弱适度变暖的感觉。与其他常见的化学刺激物相比，薄荷醇的刺激性似乎被冷却增强，被加热抑制;这表明其感官刺激性可能归因于高阈值冷纤维或冷敏感伤害感受器的刺激。
Psychophysical measurements were made of the sensory effects of l-menthol applied topically to the forearm under controlled thermal conditions. In the first experiment, subjects judged the intensity and quality of sensations produced by warming or cooling the skin in the presence of menthol or the vehicle. During cooling, menthol intensified cutaneous sensations and increased reports of burning. During warming, menthol intensified sensations transiently at low temperatures and weakened them lastingly at higher temperatures; the frequency of reports of burning varied with intensity. A second experiment tested the hypothesis that menthol would lower the threshold for warmth and raise the threshold for heat pain. No change in either threshold was observed. The primary sensory effects of l-menthol on hairy skin are therefore to heighten the perception of cooling and to attenuate the perception of moderate warming. In contrast with other common chemical irritants, menthol's pungent qualities appear to be enhanced by cooling and suppressed by warming; this suggests that its sensory irritancy may be attributable to the stimulation of a population of high-threshold cold fibers or cold-sensitive nociceptors.