No association between parental or subject occupation and brain tumor risk.
No association between parental or subject occupation and brain tumor risk.
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DOI：
10.1158/1055-9965.epi-08-0035
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发表时间：
2008-07
期刊：
影响因子：
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通讯作者：
Kaohsiung Brain Tumor Research Group
中科院分区：
文献类型：
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作者：
Mazumdar M;Liu CY;Wang SF;Pan PC;Wu MT;Christiani DC;Kaohsiung Brain Tumor Research Group
材料和方法研究设计关于我们研究设计的细节(202个病例和501个对照)已经在前面描述过(7-9)。简而言之，这是一项以人口为基础的病例对照研究，在台湾南部的工业化城市高雄进行，高雄是一个拥有大量石油工业的城市。受试者是在1997年11月至2005年12月之间招募的。通过(A)在高雄三家大型转诊医院建立的快速病例确定系统和(B)筛选台湾卫生署的癌症登记档案来识别和招募病例。所有病例都由高雄医科大学医院的病理学家复查。符合条件的病例包括所有经病理证实的脑部原发病例(良性和恶性：国际疾病分类-9代码191-192、194.3-194.4和225)，年龄0至29岁，目前居住在研究区域。最初审查的脑瘤病例中有84%参与了这项研究。对照是研究地区的非癌症居民，他们是根据台湾政府的个人身份号码系统从人口登记数据中随机选择的。每个病例与年龄(±1岁)和性别的3个对照组相匹配。在最初联系的人中，61%的预期控制组同意参与这项研究。与父母和/或受试者进行面对面访谈，以收集关于描述性特征、病史以及环境、职业和行为因素的信息。在我们的病例中，脑肿瘤的组织学和位置如表1所示。研究人群的人口统计学信息如表2所示。
Materials and MethodsStudy DesignDetails regarding the design of our study (202 cases and 501 controls) have been previously described (7–9). Briefly, this is a population-based case-control study conducted in the metropolitan area of Kaohsiung, an industrialized city in southern Taiwan with a large petroleum industry. Subjects were recruited between November 1997 and December 2005. Incident cases were identified and recruited through (a) a rapid case ascertainment system set up in three large referral hospitals in Kaohsiung and (b) screening the Cancer Registry File from the Taiwan Department of Health. All cases were reviewed by a pathologist in Kaohsiung Medical University Hospital. Eligible cases included all pathologically confirmed incident primary brain cases (benign and malignant: International Classification of Diseases-9 codes 191–192, 194.3–194.4, and 225), ages 0 to 29 years, and currently residing in the study area. Eighty-four percent of brain tumor cases initially reviewed were enrolled in the study. Controls were cancer-free residents of the study area, selected randomly from the population registry data based on the personal identification number system of the Taiwanese government. Each case was matched with three controls on age (±1 year) and sex. Of those initially contacted, 61% of prospective controls agreed to participate in the study. In-person interviews were conducted with the parents and/or subjects to collect information regarding the descriptive characteristics, medical history, as well as environmental, occupational, and behavioral factors. The histology and location of the brain tumors in our cases are presented in Table 1. Demographic information on the study population is displayed in Table 2.