Getting more for your marrow: boosting hematopoietic stem cell numbers with PGE2.
Getting more for your marrow: boosting hematopoietic stem cell numbers with PGE2.
复制标题
DOI：
10.1016/j.yexcr.2014.07.030
复制
发表时间：
2014-12-10
影响因子：
3.7
通讯作者：
Zon, Leonard I.
中科院分区：
文献类型：
--
作者：
Hagedorn, Elliott J.;Durand, Ellen M.;Fast, Eva M.;Zon, Leonard I.
关键词：
在个体的一生中，造血干细胞（hsc）自我更新并分化成包括红细胞、血小板和所有免疫细胞的谱系。造血干细胞移植为许多造血和非造血恶性肿瘤以及免疫和遗传疾病提供了潜在的治愈治疗。有限的免疫匹配供体减少了许多需要HSC移植的患者的可行选择，特别是那些不同种族和民族背景的患者。由于可快速获得和不太严格的免疫匹配要求，脐带血（UCB）已成为可移植造血干细胞的宝贵来源。对于治疗体型较大的儿童或成人，单个UCB单位含有的造血干细胞数量不够理想，因此，扩大体外UCB造血干细胞用于移植具有很大的临床兴趣。在这篇综述中，我们讨论了使用小脂质介质dmPGE2增加移植用HSC数量的最新研究和未来的治疗途径。dmPGE2最初是在斑马鱼的化学筛选中发现的，现在已经进入II期临床试验，用于治疗正在接受UCB移植的白血病和淋巴瘤患者。
Throughout the lifetime of an individual, hematopoietic stem cells (HSCs) self-renew and differentiate into lineages that include erythrocytes, platelets and all immune cells. HSC transplantation offers a potentially curative treatment for a number of hematopoietic and non-hematopoietic malignancies as well as immune and genetic disorders. Limited availability of immune-matched donors reduces the viable options for many patients in need of HSC transplantation, particularly those of diverse racial and ethnic backgrounds. Due to rapid availability and less stringent immune-matching requirements, umbilical cord blood (UCB) has emerged as a valuable source of transplantable HSCs. A single UCB unit contains a suboptimal number of HSCs for treating larger children or adults and there has thus been great clinical interest in expanding UCB HSCs ex vivo for use in transplantation. In this review we discuss the latest research and future avenues for the therapeutic use of small lipid mediator dmPGE2 to expand HSC numbers for transplantation. Originally identified in a chemical screen in zebrafish, dmPGE2 has now advanced to a phase II clinical trial as a therapy for patients with leukemia and lymphoma who are undergoing UCB transplantation.
登录
查看更多内容
影响因子：
64.5
作者：
Goessling W;North TE;Loewer S;Lord AM;Lee S;Stoick-Cooper CL;Weidinger G;Puder M;Daley GQ;Moon RT;Zon LI
通讯作者：
Zon LI
影响因子：
64.8
作者：
Genovese, Pietro;Schiroli, Giulia;Escobar, Giulia;Di Tomaso, Tiziano;Firrito, Claudia;Calabria, Andrea;Moi, Davide;Mazzieri, Roberta;Bonini, Chiara;Holmes, Michael C.;Gregory, Philip D.;van der Burg, Mirjam;Gentner, Bernhard;Montini, Eugenio;Lombardo, Angelo;Naldini, Luigi
通讯作者：
Naldini, Luigi
影响因子：
9.2
作者：
Feng, Yi;Renshaw, Stephen;Martin, Paul
通讯作者：
Martin, Paul
影响因子：
4.8
作者：
Fujino, H;West, KA;Regan, JW
通讯作者：
Regan, JW
影响因子：
20.3
作者：
Austin, TW;Solar, GP;Matthews, W
通讯作者：
Matthews, W