Antibiotic resistance: a rundown of a global crisis.
Antibiotic resistance: a rundown of a global crisis.
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DOI：
10.2147/idr.s173867
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发表时间：
2018
影响因子：
3.9
通讯作者：
Baloch Z
中科院分区：
文献类型：
--
作者：
Aslam B;Wang W;Arshad MI;Khurshid M;Muzammil S;Rasool MH;Nisar MA;Alvi RF;Aslam MA;Qamar MU;Salamat MKF;Baloch Z
致病菌中多重耐药性的出现正危及抗生素的价值，抗生素此前已经改变了医学科学。抗菌素耐药性危机归因于这些药物的滥用，以及由于严格的监管要求和经济激励减少导致新药无法获得。需要通过研究新出现的微生物、耐药机制和抗菌药物来全面努力降低耐药速度。医疗保健机构以及环境和农业部门都需要多学科方法。包括益生菌、抗体和疫苗在内的渐进式替代方法在试验中已显示出有希望的结果，表明这些替代方法在未来可作为预防性或辅助疗法发挥作用。
The advent of multidrug resistance among pathogenic bacteria is imperiling the worth of antibiotics, which have previously transformed medical sciences. The crisis of antimicrobial resistance has been ascribed to the misuse of these agents and due to unavailability of newer drugs attributable to exigent regulatory requirements and reduced financial inducements. Comprehensive efforts are needed to minimize the pace of resistance by studying emergent microorganisms, resistance mechanisms, and antimicrobial agents. Multidisciplinary approaches are required across health care settings as well as environment and agriculture sectors. Progressive alternate approaches including probiotics, antibodies, and vaccines have shown promising results in trials that suggest the role of these alternatives as preventive or adjunct therapies in future.