Nitroxyl (HNO) release from new functionalized N-hydroxyurea-derived acyl nitroso-9,10-dimethylanthracene cycloadducts.
Nitroxyl (HNO) release from new functionalized N-hydroxyurea-derived acyl nitroso-9,10-dimethylanthracene cycloadducts.
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DOI：
10.1016/j.bmcl.2004.08.062
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发表时间：
2004-11
影响因子：
2.7
通讯作者：
Bu‐Bing Zeng;Jinming Huang;M. Wright;S. King
中科院分区：
文献类型：
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作者：
Bu‐Bing Zeng;Jinming Huang;M. Wright;S. King
N-羟基脲衍生的酰基亚硝基化合物和 9,10-二甲基蒽环加合物的热逆狄尔斯-阿尔德分解，随后酰基亚硝基化合物水解产生一氧化二氮，这是硝酰基形成的证据，硝酰基是一氧化氮的单电子还原形式，因其在生物系统中的潜在作用而引起了广泛关注。 EPR 和 NMR 光谱分别为硝酰基的形成和动力学信息提供了进一步的证据。此类化合物可能被证明是有用的替代硝酰基供体。
A thermal retro-Diels–Alder decomposition of N-hydroxyurea-derived acyl nitroso compounds and 9,10-dimethylanthracene cycloadducts followed by acyl nitroso compound hydrolysis produces nitrous oxide, evidence for the formation of nitroxyl, the one-electron reduced form of nitric oxide that has drawn considerable attention for its potential roles in biological systems. EPR and NMR spectroscopy provide further evidence for nitroxyl formation and kinetic information, respectively. Such compounds may prove to be useful alternative nitroxyl donors.