Chicken CD1 genes are located in the MHC:: CD1 and endothelial protein C receptor genes constitute a distinct subfamily of class-I-like genes that predates the emergence of mammals
Chicken CD1 genes are located in the MHC:: CD1 and endothelial protein C receptor genes constitute a distinct subfamily of class-I-like genes that predates the emergence of mammals
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DOI：
10.1007/s00251-005-0016-y
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发表时间：
2005-09-01
期刊：
影响因子：
3.2
通讯作者：
Kasahara, M
中科院分区：
文献类型：
--
作者：
Maruoka, T;Tanabe, H;Kasahara, M
哺乳动物有几个主要组织相容性复合体(MHC)-I类基因。虽然它们中的一些被认为起源于哺乳动物出现之前，但I类基因的起源却鲜为人知。我们分析了最近发布的鸡基因组草稿序列，并鉴定了两个I类基因家族：CD1和proR(内皮蛋白C受体的基因)。鸡有两个CD1基因，分别命名为CD1.1和CD1.2，它们位于彼此相距840bp的串联位置。鸡CD1.1和CD1.2既不是第1组，也不是第2组，说明这两组CD1起源于哺乳动物。虽然该数据库没有提供它们的染色体定位信息，但我们发现鸡CD1基因位于16号染色体上先前描述的MHC B系统重叠群附近。我们通过双色荧光原位杂交证实了CD1与B系统的连锁。鸡只有一份PROCR。在已知的I类基因中，proR与CD1的亲缘关系最为密切，这表明CD1和proR构成了早于哺乳动物出现的I类基因的一个不同的亚家族。
Mammals have several major histocompatibility complex (MHC) class-I-like genes. Although some of them are assumed to have originated before the emergence of mammals, the origin of class-I-like genes is poorly understood. We analyzed here the recently released chicken draft genome sequence and identified two families of class-I-like genes: CD1 and PROCR (the gene for the endothelial protein C receptor). Chickens have two CD1 genes, designated CD1.1 and CD1.2, located in tandem similar to 840 bp apart from each other. Chicken CD1.1 and CD1.2 are neither group 1- nor group 2-like, indicating that the two groups of CD1 emerged in a mammalian lineage. Although the database provides no information as to their chromosomal localization, we found that chicken CD1 genes are located adjacent to the previously characterized MHC B system contig on chromosome 16. We confirmed the linkage of CD1 to the B system by dual-color fluorescence in situ hybridization. Chickens have a single copy of PROCR. Among known class-I-like genes, PROCR is most closely related to CD1, indicating that CD1 and PROCR constitute a distinct subfamily of class-I-like genes that predates the emergence of mammals.