Human papillomavirus (HPV) infection in heterosexual South African men attending sexual health services: associations between HPV and HIV serostatus
Human papillomavirus (HPV) infection in heterosexual South African men attending sexual health services: associations between HPV and HIV serostatus
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DOI：
10.1136/sti.2009.037598
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发表时间：
2010-06-01
影响因子：
3.6
通讯作者：
Lewis, David A.
中科院分区：
文献类型：
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作者：
Mueller, Etienne E.;Chirwa, Tobias F.;Lewis, David A.
目的探讨性活跃男性生殖器疣（anogenital warts，GW）、男性尿道分泌物和无症状男性中人乳头瘤病毒（human papillomavirus，HPV）基因型的分布及HPV感染与HIV合并感染的关系。56名尿道分泌物综合征男性和50名无症状男性接受艾滋病毒自愿咨询和检测。使用线性阵列HPV基因分型检测来确定研究参与者中的HPV基因型分布。使用两种商业快速检测试剂盒检测血清中的HIV抗体。结果研究参与者中肛门生殖器HPV的患病率为78%（166）。100%（108）的GW、48%（27）的尿道分泌物综合征男性和62%（31）的自愿咨询和检测参与者中检测到HPV DNA。HPV 6、11、16和18型在81%（134）的所有HPV阳性研究参与者中作为单一或联合感染流行。HPV 6型和/或11型在GW患者中显著较高（p
Objectives To investigate the distribution of human papillomavirus (HPV) genotypes and determine the associations between HPV infection and HIV coinfection in sexually active heterosexual men with anogenital warts (GW), male urethral discharge or asymptomatic men.Methods Valid specimens for HPV genotyping were obtained from three patient groups consisting of 108 men with GW, 56 men with urethral discharge syndrome and 50 asymptomatic men attending for HIV voluntary counselling and testing. The Linear Array HPV Genotyping Test was used to determine the HPV genotype distribution among study participants. Sera were tested for HIV antibodies using two commercial rapid tests.Results The prevalence of anogenital HPV among study participants was 78% (166). HPV DNA was detected in 100% (108) of GW, 48% (27) of men with urethral discharge syndrome and 62% (31) of voluntary counselling and testing participants. HPV types 6, 11, 16 and 18 were prevalent as either single or combined infections in 81% (134) of all HPV-positive study participants. HPV types 6 and/or 11 were significantly higher among GW patients (p