Elevated quinolinic acid levels in cerebrospinal fluid in subacute sclerosing panencephalitis
Elevated quinolinic acid levels in cerebrospinal fluid in subacute sclerosing panencephalitis
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DOI：
10.1016/j.jneuroim.2019.577088
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发表时间：
2020-02-15
影响因子：
3.3
通讯作者：
Hasegawa, Shunji
中科院分区：
文献类型：
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作者：
Inoue, Hirofumi;Matsushige, Takeshi;Hasegawa, Shunji
亚急性硬化性全脑炎（SSPE）是一种罕见的神经退行性疾病所造成的持续感染异常麻疹病毒。吲哚胺-2，3-双加氧酶（IDO）启动犬尿氨酸途径（KP）代谢物喹啉酸（QUIN）的增加的产生，其对神经元具有兴奋毒性作用。我们测量了血清IDO活性和脑脊液（CSF）中QUIN的水平。SSPE患者的CSF QUIN水平显著高于对照组，并根据研究患者的神经功能障碍而增加。CSF QUIN的升高和SSPE的进展表明KP代谢在炎症性神经破坏中的病理作用。
Subacute sclerosing panencephalitis (SSPE) is a rare neurodegenerative disorder caused by a persistent infection with aberrant measles virus. Indoleamine-2, 3-dioxygenase (IDO) initiates the increased production of kynurenine pathway (KP) metabolites quinolinic acid (QUIN), which has an excitotoxic effect for neurons. We measured serum IDO activity and cerebrospinal fluid (CSF) levels of QUIN. The CSF QUIN levels were significantly higher in SSPE patients than in controls, and increased according as neurological disability in a patient studied. Elevation of CSF QUIN and progression of SSPE indicate a pathological role of KP metabolism in the inflammatory neurodestruction.